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阿德福韦酯—海藻酸钠多壁碳纳米管复合物的体外缓释行为 被引量：3

Sustained release behavior of complex of ALG-MWNT-ADV in vitro
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摘要 目的以阿德福韦酯(ADV)为模型药物,研究多壁碳纳米管(MWCNTs)作为缓释载体的可行性。方法通过海藻酸钠(ALG)修饰处理MWCNTs,改善其表面性质,利用透射电镜表征了修饰后的MWCNTs的表面形貌,借助全自动快速比表面积及孔隙度分析仪表征MWCNTs的比表面积和孔结构,并探讨ALG-MWCNTs-ADV复合物在0.2%十二烷基硫酸钠磷酸盐缓冲液中的缓释行为。结果 MWCNTs经过修饰后制备得到的ALG-MWCNTs-ADV复合物缓释效果良好,释放动力学基本符合Higuchi模型。结论 MWCNTs可作为药物缓释载体材料。 Purpose To investigate the possibility of multi-walled carbon nanotubes（MWNTs） as a drug carrier to combine adefovir dipivoxil and to explore the potential feasibility of MWNTs.Methods Surface properties were improved by sodium alginate.Scanning electron microscope（TEM） and automated specific surface area and pore size analysis were used to characterize surface morphology,pore diameter and surface area of MWNTs,and the sustained release behavior of complex of ALG-MWNTs-ADV was investigated in 0.2% SDS-PBS solution.Results The sustained release effects of complex was excellent in 0.2% SDS-PBS solution.And the release dynamics of ALG-MWNTs-ADV was in accordance with the Higuchi model.Conclusion MWNTs could be used as a drug carrier for sustained-release preparations.
作者 万洪善
机构地区 连云港职业技术学院
出处 《中国生化药物杂志》 CAS CSCD 北大核心 2012年第4期358-360,364,共4页 Chinese Journal of Biochemical Pharmaceutics
基金 国家重点建设专业资助项目 江苏省优秀教学团队资助项目 连云港市2011年科技攻关项目(CG1111)
关键词 阿德福韦酯 海藻酸钠 多壁碳纳米管 缓释 adefovir dipivoxil alginate sodium multi-walled carbon nanotubes sustained release
分类号 R944.9 [医药卫生—药剂学]
  • 相关文献

参考文献15

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二级参考文献26

  • 1吕春祥,凌立成,袁淑霞,梁栋,李永红.硝苯地平在球状活性炭中的吸附及缓释行为[J].新型炭材料,2007,22(1):17-22. 被引量：16
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共引文献4

同被引文献25

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引证文献3

二级引证文献10

中国生化药物杂志
2012年 第4期

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