我院儿科病区抗菌药物应用情况与细菌耐药性分析

Analysis of the Application of Antibacterial Agents and Bacterial Resistance in Paediatrics Wards of Our Hospital

目的:了解我院儿科病区抗菌药物的应用情况及常见病原菌的耐药率。方法:回顾性分析我院2009-2011年儿科病区的抗菌药物用药频度(DDDs),并统计培养分离出的病原菌分布、构成及其耐药率。结果:头孢菌素类、大环内酯类及青霉素类药是我院儿科病区防治感染的主要品种,第3代头孢菌素在我院的DDDs逐年增高。临床分离菌中最常见的菌种为大肠埃希菌、表皮葡萄球菌、肺炎克雷伯菌、金黄色葡萄球菌和粪肠球菌。结论:抗菌药物的DDDs与细菌耐药率密切相关,应进一步加强抗菌药物应用监管,以降低细菌耐药率。

OBJECTIVE：To analyze the change of the bacterial resistance and the application of antibacterial agents in paediatrics wards of our hospital.METHODS：The DDDs of commonly used antibacterial agents was analyzed in our hospital from 2009 to 2011 retrospectively,and the distribution,constitution and drug resistance of pathogenic bacteria were analyzed statistically.RESULTS：Cephalosporins,macrolides and penicillins were the main anti-infective drugs in paediatrics wards of our hospital.The DDDs of third-generation cephalosporins increased year by year.Top 5 pathogenic bacteria were Escherichia coli,Staphylococcus epidermidis,Klebsiella pneumoniae,Staphylococcus aureus and Enterococcus faecalis.CONCLUSION：The DDDs of antibacterial agents is closely correlated with bacterial resistance.Antibacterial agents monitoring should be enhanced to reduce bacterial resistance rates.