高危人群对CHD药物洗脱支架择期植入前后中医证型分布及演变规律影响的研究

The Study on Changes of Traditional Chinese Medicine Syndrome in CHD with Dangerous People around Intervention Treatment with DES in Selected Date

目的:探讨高危人群对冠心病(CHD)药物洗脱支架植入前后中医证型演变规律的影响。方法:对两家三甲医院131例术前诊断为冠心病的高危人群且符合其它各项标准的病例,根据性别按术前、术后24小时、术后1周、术后1月、术后3月、术后6月完成中医病史的采集及证型的辨别,最后进行整理、统计和分析。结果:气滞证在术前至术后1月的分布均具有明显差异(P<0.05或P<0.01),血瘀证在术前、术后24小时、术后1周、术后3月的分布有明显差异(P<0.05或P<0.01),寒凝证、气虚证在各阶段的分布均具有明显差异(P<0.05或P<0.01),阴虚证在术后24小时、术后1周、术后1月、术后6月的分布有明显差异(P<0.05或P<0.01),阳虚证的分布在术后1月至术后6月均具有明显差异(P<0.05或P<0.01)。结论:高危人群主要影响CHD药物洗脱支架择期植入前后的本虚证,对其气滞、血瘀也有不同程度的影响。

Objective： To explore distribution and changing rule around intervention treatment with DES implanted of Tradi-tional Chinese Medicine （TCM） syndromes in CHD with dangerous people, and the influence of syndrome on account of PCI. Methods： The syndromes of 131patients of CHD implanted DES with dangerous people were analyzed according to six different times around PCI ： before, after 24 hours, after 1 week, after 1 month, after 3 months, after 6 months. Results ： The distribu-tion of Qi stagnation syndrome had significant difference before PCI to after 1 month; the distribution of blood stasis syndrome be-fore PCI, after 24 hours, after 1 week, after 3 month also had significant difference ; cold coagulation syndrome and Qi deficien-cy syndrome had a significant difference at every times （P〈0. 05 or P〈0. 0l ） ; it had significant difference by Yin deficiency syn-drome after PCI 24 hours, 1 week, 1 month and 6 month （P〈0. 05 or P〈0.01 ）, Yang deficiency syndrome after PCI 1 month to 6 month （P〈0. 05 or P〈0. 01 ）, too. Conclusions ： It＇s root asthenic syndromes had a significant decrease and Qi stagnation and blood stasis of branch sthenic syndrome had a significant decrease too.