摘要
观察意外死亡正常人(N=10)及烧伤后MOF病人(N=10)脏器含水量的变化。发现烧伤后MOF病人各类脏器中无论有无功能衰竭含水量皆增加,但功能衰竭者高于无功能衰竭者,以脏器血管外水量增加更显著。示烧伤后MOF病人各脏器皆有水肿,只是程度不同而已,且与其功能障碍程度一致。其残留血液水量变化各异;心、肺及胃肠等表现为充血和/或瘀血,而肾为缺血。脏器含水量的异常变化,可能是MOF的共同病理基础,在烧伤后MOF发病中占重要地位。
Water contents of lung, heart, kidney, liver, gastrointestine, and spleen in accident victims with good health (N=10) and patients with postburn multiple organ failure (PBM- OF) (N=10) were measured. It was found that organ water content of all visceral organs was increased markedly in PBMOF patients. Moreover, the severity of increased organ water content was paralled with the severity of organ failure. However, there were some differences between the results of the estimated blood volume in different organs. The pulmonary, cardiac and gastrointestinal residual blood water volumes were increased in these patients with PBM- OF, indicating that congestion and/or sludging were superimposed in these organs. In con- tract, the renal and spleen residual blood water volumes were decreased, indicating that these organs were suffered from ischemia. On the other hand, the hepatic residual blood water volume was declined in these PBMOF without hepatic failure. However, it was in- creased in those with hepatic failure. These results suggested that the increase of organ water content might play an impor- tant role in the pathogenesis of organ failure.
