摘要
我们观察了内毒素所致肠源性感染与肠粘膜形态学改变和黄嘌呤氧化酶、黄嘌呤脱氢酶活性变化之间的相关性。结果显示,循环中的内毒素主要是损伤回肠和盲肠粘膜屏障,导致肠源性细菌感染。同时回肠和盲肠粘膜中黄嘌呤氧化酶和黄嘌呤脱氢酶活性显著增高,本文对此进行了讨论。
It has been ducumented that endotoxin could induce gut origin infection. Consequently, experiments were performed to correlate endotoxin-induced gut origin infection with changes in intestinal mucosal structure and xanthine dehydrogenase and oxidase activity. Bacteria infection from the intestines to extrantestinal organs in 70% of the mice receiving endotoxin. Endotoxin injured primarily the ileal and cecal mucosa and increased ileal and hepatic xanthine dehydrogenase and cecal oxidase activities(P<0.05). These results suggest that xanthine oxidase-induced mucosal damage plays a role in endotoxin-induced gut origin infection.
