肾病综合征与糖尿病肾病的血脂代谢特点分析

THE ANALYSIS OF LIPID METABOLISM CHARACTERISTICS BETWEEN NEPHROTIC SYNDROME AND DIABETIC NEPHROPATHY

目的分析比较原发性肾病综合征和糖尿病肾病患者血脂异常的特点。方法选择2008年12月～2010年12月在我院肾病内科以及内分泌科住院的70名原发性肾病综合征患者和70例糖尿病肾脏疾病患者,比较两组患者各血脂指标是否存在差异。结果原发性肾病综合征患者血脂异常的发生率为98.6%,高于糖尿病肾病患者90.0%的血脂异常发生率,且差异具有统计学意义;其中肾功能正常时,肾病综合征患者TC、HDL和LDL水平均明显高于糖尿病肾病患者,在肾功能下降的人群之中,TC、LDL的差异虽仍有统计学意义,但在数值上差距减小,HDL的差异并没有统计学意义。结论TC和LDL在两组患者中的差异较为明显,在临床上可以考虑作为鉴别原发性肾病综合征和糖尿病肾病的血脂方面指标。

Objective To analyze the lipid metabolism characteristics between nephrotic syndrome and diabetic nephropathy. Methods 70 inpatients with nephrotic syndrome and 70 inpatients with diabetic nephropathy who came to our hospital fi＇om Dee 2008 to Dec 2010 were recruited in this study. Blood lipid parameters of each patient were tested to explore if there was difference between these two kinds of disease. Results The Incidence of dyslipoproteinemia among patients with nephrotic syndrome was 98.6%, which was higher than that of patients with diabetic nephropathy （90.0%） and the difference was statistical significant. TC, HDL and LDL of patients with nephrotic syndrome were markedly higher than those of patients with diabetic nephropathy among people with normal renal function ; while in patients with impaired renal function, the difference of TC, LDL still had significance though having reduced, but the difference of HDL had not statistic significance yet. Conclusion The difference of TC and LDL between the two groups of pa- tients were more significant and thus could be used as lipid profile indicators to identify primary nephrotic syndrome and diabetie ne- phropathy