血吸虫病肝纤维化发病机制及相关药物作用靶点的研究进展

Research progress in pathogenic mechanism of schistosomiasis hepatic fibrosis and related drugs targets

血吸虫病肝纤维化及血吸虫病虫卵肉芽肿是由于血吸虫虫卵沉积在宿主的肝脏及结肠肠壁等组织引起宿主对致病因子的免疫应答而产生的病理变化。该文对国内外报道的血吸虫虫卵所致的肝纤维化致病机制及治疗药物进行综述。

Schistosomiasis liver fibrosis and schistosomiasis egg granuloma is due to deposition of schistosome eggs in the host liver and colon wall tissue and the subsequent pathological changes as a result of the immune responses between host and the etiological agents. This article mainly reviewed the pathogenic mechanism of hepatic fibrosis induced by schistosome egg and the antischistosomal drugs at home and abroad.