外寒对小鼠血清与呼吸道抗体的影响

Effects of External Cold on Antibody in Sera and Respiratory of Mice

目的:观察外寒对小鼠血清lgG(IgG-S)和呼吸道lgG(IgG-R)的影响。方法:50只昆明小鼠随机分为5组:常温对照组、4℃7天组、4℃14天组、0℃7天组、0℃14天组,置于人工气候箱中处理后取小鼠胸腺与脾脏称重,ELISA法检测IgG-S和IgG-R。结果:4℃7天组、4℃14天组、0℃7天组、0℃14天组小鼠胸腺系数和脾脏系数较常温对照组降低,IgG-S和IgG-R较常温对照组明显升高,差异具有显著性意义。结论:外寒伤阳,肺卫受损,机体免疫力降低,肺部出现感染导致IgG浓度升高。

Objective：To investigate the effects of external cold on IgG-S and IgG-R of mice.Methods：50 Kun-min mice were divided into five groups：normal,4℃/7d group,4℃/14d group,0℃/7d group and 0℃/14d group.They were put into different temperature-controlled boxes,then samples were collected to measure IgG-S and IgG-R with ELISA and the thymus and spleen were weighed.Results：Compared with the normal group,IgG-S and IgG-R of the 4℃/7d group,4℃/14d group,0℃/7d group and 0℃/14d group were higher,the spleen coefficient and thymus coefficient were significantly reduced（P〈0.05）.Conclusion：The external cold impaired yang and damaged the immunological function,which induced the pulmonary infection and the elevation of the IgG.