补肾活血法对动脉粥样硬化血小板膜糖蛋白活性影响的研究

Clinical Study of Bushen Huoxue Treatment on Molecular Echanisms of Coronary Heart Disease

目的:观察补肾活血对动脉粥样硬化血小板膜糖蛋白活性的影响,探讨其作用的分子机制。方法:将200例动脉粥样硬化患者随机分为对照组和实验组各100例,对照组口服用辛伐他汀和氯吡格雷,实验组加服补肾活血方剂,均治疗12周;比较观察两组临床疗效并测定血小板膜糖蛋白。结果:实验组与对照组临床疗效和血小板膜糖蛋白表达有显著性差异(P<0.05)。结论:补肾活血法治疗动脉粥样硬化临床疗效显著,可能是通过血小板膜糖蛋白途径起作用。

Objective：To observe Bushen Huoxue treatment effect on platelet membrane proteins and to explore the molecular mechanisms.Methods：200 patients with atherothrombotic infarction were randomly divided into two groups：control group received Simvastatin and Clopidogrel（n=100）and experimental group plus prescription Bushenhuoxue（n=100）,compared two groups of clinical efficacy and platelet membrane glycoprotein after 12 weeks.Results：Experimental group and control group in the clinical efficacy and platelet membrane glycoprotein expression differences were significant.Conclusions：Bushen Huoxue treatment of atherosclerosis clinical effect is significant,probably by working on platelet membrane glycoprotein.