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促红细胞生成素对体外帕金森病模型细胞凋亡及Bax蛋白表达的影响 被引量：1

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摘要 目的观察促红细胞生成素(EPO)对体外帕金森病模型细胞凋亡及Bax蛋白表达的影响。方法体外培养多巴胺能神经元细胞加入6-OHDA建立帕金森病细胞模型,分为对照组、6-OHDA组和EPO+6-OHDA组,采用TH免疫组织化学方法和TUNEL法观察体外培养7d时细胞凋亡情况,检测Bax蛋白表达。结果与对照组比较,6-OHDA组存在明显的细胞凋亡和Bax蛋白高表达(P<0.05);与6-OHDA组比较,EPO+6-OHDA组细胞凋亡明显减少,Bax蛋白表达降低(P<0.05)。结论促红细胞生成素能减少6-羟基多巴诱导的神经元细胞凋亡,降低Bax蛋白表达。
作者 卢欣
机构地区 郑州大学基础医学院
出处 《中国实用神经疾病杂志》 2012年第14期30-32,共3页 Chinese Journal of Practical Nervous Diseases
关键词 促红细胞生成素 帕金森病 细胞凋亡 BAX蛋白
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献12

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共引文献19

同被引文献26

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中国实用神经疾病杂志
2012年 第14期

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