大理白族地区乙型肝炎流行模式与基因分型初探

Prevalence modes and genotyping of hepatitis B in Dali minority areas

目的掌握白族人群乙型肝炎的流行情况及流行模式,并对其基因分型进行初步探讨。方法在流行病调查的基础上用实时荧光定量法进行DNA载量测定及基因分型。结果 425例乙型肝炎标志物结果A组(大三阳)阳性率为24.7%;B组(小三阳)阳性率为34.4%;50例扩增例数基因分型结果B型23例,占46.0%;C型20例,占40.0%;D型5例,占10.0%;C型/D型混合感染2例,占4.0%。结论该地区乙型肝炎流行模式以小三阳为主;基因分布以B型居多,C型次之。

OBJECTIVE To study the present condition of prevalence modes and genotyping of hepatitis B epidemic in Dali minority areas.METHODS The DNA loading and genotyping were determined through real-time fluorescence quantitative method on the basis of epidemic investigation.RESULTS Of 425 cases of the markers of hepatitis B,the positive rate was 24.7% in group A（Da sanyang）,34.4% in group B（Xiao sanyang）.The results of genotyping of 50 amplified cases were： 23 cases of type-B（46.0%）,20 cases of type-C（40.0%）,5 cases of type-D（10.0%）,and 2 cases of type-C/D（4.0%）.CONCLUSION The major prevalence mode of hepatitis B in this area is Xiao sanyang,and the most prevalent genotype is type-B,and type-C.