胰岛素样生长因子Ⅱ浓度变化与阻塞性睡眠呼吸暂停低通气综合征患者认知功能的相关性

Relationship between Cognition of Obstructive Sleep Apnea/Hypopnea Syndrome Patients and Insulin-like Growth Factor Ⅱ

目的探讨OSAHS患者血清胰岛素样生长因子Ⅱ(IGF-Ⅱ)浓度与其认知功能的关系,揭示OSAHS引起认知功能障碍的可能机制.方法采用MoCA量表评定28名OSAHS患者及14名健康志愿者认知功能,采用酶联免疫吸附法检测研究对象血清IGF-Ⅱ浓度,分析研究对象血清IGF-Ⅱ浓度与认知功能、夜间低氧及睡眠结构间的关系.结果 OSAHS组血清IGF-Ⅱ浓度显著高于对照组(t=5.587,P=0.000);研究对象MoCA总分与血清IGF-Ⅱ浓度显著负相关(r=-0.483,P=0.001);研究对象血清IGF-Ⅱ浓度与AHI及S1+S2期睡眠时间长短显著正相关(r分别为0.483、0.549,P分别为0.001、0.000);与LSO、S3+S4期睡眠时间及REM睡眠时间长短显著负相关(r分别为-0.449、-0.612、-0.395,P分别为0.003、0.000、0.010).结论 OSAHS患者血清IGF-Ⅱ浓度高于正常人群,IGF-Ⅱ在OSAHS患者认知功能障碍的发病机制中可能起着重要作用.

Objective To determine the relationship of blood serum insulin like growth factor Ⅱ（IGF-Ⅱ）concentration with deterioration of cognitive function in patients with OSAHS and to explore the possible mechanism of cognitive impairment of OSAHS.Methods Twenty-eight male patients with OSAHS and fourteen normal men enrolled in the study.Polysomnography and MoCA had been conducted.Blood serum IGF-Ⅱ concentration was measured with ELISA.Results The blood serum IGF-Ⅱ concentration of OSAHS group was significantly increased compared with control group（t=5.587,P=0.000）.The blood serum IGF-Ⅱ concentration of subjects was significantly negative associated with the score of MoCA（r=-0.483,P=0.001）.It was significantly positive correlated with AHI and S1＋S2（AHI：r=0.483,P=0.001,S1＋S2：r=0.549,P=0.000）,and it was significantly negative associated with the LSO,S3＋S4 and REM（LSO：r=-0.449,P=0.003,S3＋S4：r=-0.612,P=0.000,REM：r=-0.395,P=0.010）.Conclusion The blood serum IGF-Ⅱ concentration of OSAHS is significantly increased compared with healthy people.It possibly plays a role in the mechanism of cognitive impairment of OSAHS.