慢性前列腺炎及其不育患者前列腺液的支原体分析

Analysis of Mycoplasma for prostatic fluid of patients with chronic prostatitis and sterility

目的探讨慢性前列腺炎(CP)及其不育患者前列腺液(EPS)支原体的携带情况,以了解CP患者生育力与支原体的关系。方法 CP组患者190例,将其做生育力和病理性调查的138例分为CP生育组68例,CP不育组70例,另设30例正常人作为对照组,采用常规的液体培养基进行培养、分离、鉴定,比较各组间支原体阳性率。结果 190例CP患者EPS分离支原体阳性者98例(51.58%),明显高于正常对照组(χ2=14.01,P<0.01);三组EPS支原体阳性率差异有统计学意义(χ2=26.72,P<0.01),CP不育组(68.57%)明显高于正常对照组(P<0.01);两种支原体共134株,其中单纯解脲支原体和人型支原体阳性者分别占阳性标本的53.06%(52/98)和10.20%(10/98),两者混合阳性占36.73%(36/98)。结论支原体不仅是CP的致病菌之一,而且还可能与CP所致的不育有密切的关系,解脲支原体与人型支原体两者混合感染可能是导致不育的主要病原体之一。

Objective To explore the positive rate of mycoplasma in the prostatic liquid （EPS） of patients with chronic prostatitis （CP） and sterility, and to understand the relation between the fertility of the patients with CP and mycoplasma. Methods One hundred and ninety patients with CP （the CP group）, 138 of which were divided into CP fertility group （68 cases） and CP infertility group （70 cases）. Additionally, 30 healthy individuals were selected as the control group. The positive rate of mycoplasma were detected and compared in the three groups, through culture, isolation and identification using Conventional liquid medium. Results The positive rate of mycoplasma （51.57%） in the CP group was significantly higher than that in the control group （g2=14.01, P〈0.01）. The positive rates of myco- plasma in the CP infertility group （68.57%） were significantly higher than that in the control group, with statistically marked significant difference between the three groups （Z2=26.72, P〈0.01）. Two types of mycoplasmas had 134 strains in total. The positive rates of mycoplasma urealyticum and mycoplasma hominis was 53.06% （52/98） and 10.20% （10/ 98） in the positive samples, and the rate of combined ycoplasma urealyticum and mycoplasma hominis was 36.74% （36/98）. Conclusion The mycoplasma is not only one of the pathogens of CP, but also has a close relation with the sterility caused by CP. The combined infection of mycoplasma urealyticum and mycoplasma hominis might be one of main causes of sterility.