米非司酮联合利凡诺对中期引产孕妇血清泌乳素、雌三醇、孕酮、IGFBP-1及VEGF水平的影响

Influence of Mifepristone combined with Rivanol on the levels of serum prolactin, estriol, progesterone, IGFBP-1 and VEGF in pregnant women with metaphase induced labor

目的研究米非司酮联合利凡诺对中期引产孕妇血清泌乳素、雌三醇、孕酮、IGFBP-1及VEGF水平影响。方法选取2010年2月至2012年1月进行中期引产的42例孕妇,随机分为对照组(利凡诺组)21例和观察组(米非司酮联合利凡诺组)21例,对两组孕妇引产前及注射后24h、引产后24h的血清泌乳素、雌三醇、孕酮、IGFBP-1及VEGF水平进行检测及比较。结果观察组引产后24h的血清泌乳素、雌三醇、孕酮及VEGF水平均低于对照组,而IGFBP-1高于对照组,差异有统计学意义(P<0.0)。结论米非司酮联合利凡诺对中期引产孕妇血清泌乳素、雌三醇、孕酮、IGFBP-1及VEGF水平影响大于单用利凡诺,引产效果更佳。

Objective To study the influence of Mifepristone combined with Rivanol on the levels of serum prolactin, eslriol, progesterone, IGFBP-1 and VEGF in pregnant women with metaphase induced labor. Methods Forty-two pregnant women with metaphase induced labor in our hospital from August 2010 to January 2012 were random- ly divided into the control group （Rivanol group, 21 cases） and the observation group （Mifepristone combined with Rivanol group, 21 cases）. Then the levels of serum prolactin, estriol, progesterone, IGFBP-1 and VEGF before in- duced labor, after the injection at 24 hour and after induced labor at 24 hour were detected and compared between the two groups. Results The levels of serum prolactin, estriol, progesterone and VEGF of the observation group after the injection at 24 hour and after induced labor at 24 hour were significantly lower than those of control group （P〈0.05）, and the levels of IGFBP-1 were significantly higher than that of control group （P〈0.05）. Conclusion The influence of Mifepristone combined with Rivanol on serum prolactin, estriol, progesterone, IGFBP-1 and VEGF of pregnant women with metaphase induced labor is larger than that of Rivanol. And the effect of induced labor is better.