硝酸异山梨酯治疗慢性肺源性心脏病伴心力衰竭的疗效观察

Effect of isosorbide dinitrate in patients of chronic pulmonary heart disease with heart failure

目的观察硝酸异山梨酯注射液(商品名:异舒吉)在慢性肺心病心力衰竭中的临床疗效。方法将我院于2010年1月～2011年11月住院的慢性肺心病伴心衰患者70例,随机分为2组,对照组采用常规治疗,观察组加用硝酸异山梨酯注射液(异舒吉)20mg静脉滴注,1次/d,10d为一疗程。结果硝酸异山梨酯可明显改善慢性肺心病伴心衰患者心功能,总有效率91.43%,EF改变明显,与对照组比较,P<0.05;观察组中血气分析PaO2和PaCO2明显改善,与对照组比较,P<0.05;未见明显不良反应。结论硝酸异山梨酯在治疗慢性肺心病伴心衰患者中疗效确切,不良反应少,值得临床推广。

Objective To observe the clinic effect of isosorbide dinitrate injection in patients of chronic pulmonary heart disease with heart failure.Methods 70 patients were randomized to treatment group（n=35） and control group（n=35）.To give conventional therapy to control group.To add isosorbide dinitrate injection to treatment group：20mg ivgtt qd×10days.Results Isosorbide dinitrate injection can improve obviously heart function,totol effective rate of treatment 91.43%,EF of treatment improved,compared with control group,P〈0.05;PaO2 and PaCO2 of treatment group improved obviously,compared with control group,P〈0.05;to have no adverse reaction.Conclusion Effect of isosorbide dinitrate injection in patients of chronic pulmonary heart disease with heart failure was sure.It was worth of clinical spread.