阻塞性睡眠呼吸暂停综合征合并高血压患者颈动脉内皮功能和血清C-反应蛋白水平变化的意义

Analysis the correlation between serum C-reactive protein and IMT in patients with OSAS complicating with essential hypertension

目的探讨在阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)合并高血压患者血清C-反应蛋白(CRP)及颈动脉内膜中层厚度(IMT)的变化及相互关系。方法采用高分辨率超声检测健康对照组、OSAS组、高血压组和OSAS合并高血压组患者IMT。采用速率散射免疫比浊法检测各组患者血清CRP水平。结果 OSAS合并高血压组患者IMT、血清CRP水平显著高于健康对照组、单纯OSAS组和单纯高血压组(P<0.05)。检验结果显示,CRP升高与IMT之间有统计学意义(P<0.05),OR(95%CI)为4.329(3.837～5.641)。结论血清CRP水平可以作为OSAS合并高血压患者将来发生心血管病变的预测指标。

Objective To investigate the correlation between C-reactive protein （CRP） and carotid arterial intimamadia thickness （IMT） of patients with obstructive sleep apnea syndrome. Methods The carotid arterial intimamadia thickness was determined by high resolution ultrasonography. The serous concentration of C-reactive protein was detected by velocity scatter immunoturbidimetry. Results Compared with health control group, OSAS group, and essential hypertension （EH） group, IMT were significantly greater in patients with OSAS ＋ EH （P 〈 0. 05 ） ; CRP were significantly higher （P 〈 0. 05 ）. The results showed that significant linear association between CRP and IMT. Conclusion Serous concentration of CRP is an prognostic indicatrix for patients with OSAS ＋ EH.