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曲尼司特对转化生长因子-β_1诱导的心脏成纤维细胞表型转化的影响 被引量：1

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摘要 心肌纤维化可由多种心血管疾病导致．主要表现为成纤维细胞表型发生转化．成为具有更强增殖及分泌能力的肌成纤维细胞．心肌细胞外基质（extracellularnlatrix．ECM）合成增加、心肌细胞凋亡及肥大等．其中心肌成纤维细胞表型转化是心肌发生纤维化的关键环节。随着心肌纤维化的发展，
作者 刘虎子 刘爱军
机构地区 山西省心血管病医院医务科 北京安贞医院小儿心脏中心
出处 《中国药物与临床》 CAS 2012年第8期1018-1020,I0002,共4页 Chinese Remedies & Clinics
关键词 细胞表型转化 肌成纤维细胞 转化生长因子-β1 曲尼司特 心肌细胞外基质 心肌纤维化 心脏 心肌细胞凋亡
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献8

  • 1Van den Borne SW, Diez J, Blankesteijn WM, et al. Myocardial remodeling after infarction: the role of myofibroblasts. Nat Rev Cardiol, 2010,7:30-37.
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二级参考文献9

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  • 2刘英,廖玉华,程翔,李彬,葛洪霞,张玲,郭张强.急性心肌梗死后心脏TGF-Β_1的表达和心室重塑(英文)[J].中国病理生理杂志,2005,21(12):2305-2309. 被引量：11
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  • 9Shiota N, Okunishi H, Takai S, et al. Tranilast suppresses vascular chymase expression and neointima formation in balloon-injured dog carotid artery[J]. Circulation, 1999, 99(8): 1084-1090.

共引文献2

同被引文献18

  • 1Moon TC, Befus AD, Kulka M. Mast cell mediators: their differential release and the secretory pathways involved[J]. Front Immunol, 2014, 5: 569.
  • 2Higuchi H, Hara M, Yamamoto K, et al. Mast cells play a critical role in the pathogenesis of viral myocarditis[J]. Circulation, 2008, 118(4): 363-372.
  • 3Hügle T. Beyond allergy: the role of mast cells in fibrosis[J]. Swiss Med Wkly, 2014, 144: w13999.
  • 4Kunzmann S, Schmidt-Weber C, Zingg JM, et al. Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling[J]. J Allergy Clin Immunol, 2007, 119(6): 1398-1407.
  • 5Cicha I, Yilmaz A, Klein M, et al. Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro[J]. Arterioscler Thromb Vasc Biol, 2005, 25(5): 1008-1013.
  • 6Mason RM. Fell-Muir lecture: Connective tissue growth factor (CCN2) --a pernicious and pleiotropic player in the development of kidney fibrosis[J]. Int J Exp Pathol, 2013, 94(1): 1-16.
  • 7Daniels JT, Schultz GS, Blalock TD, et al. Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring[J]. Am J Pathol, 2003, 163(5): 2043-2052.
  • 8Tank J, Lindner D, Wang X, et al. Single-target RNA interference for the blockade of multiple interacting proinflammatory and profibrotic pathways in cardiac fibroblasts[J]. J Mol Cell Cardiol, 2014, 66: 141-156.
  • 9Sharma A, Abraham T, Sampaio A, et al. Sodium cromolyn reduces expression of CTGF, ADAMTS1, and TIMP3 and modulates post-injury patellar tendon morphology[J]. J Orthop Res, 2011, 29(5): 678-683.
  • 10白寿军,张亚敏,李彩霞,徐钢,刘晓城.曲尼司特对TGF-β_1刺激的人肾小管上皮细胞表达结缔组织生长因子的影响[J].华中科技大学学报（医学版）,2009,38(4):477-480. 被引量：3

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二级引证文献6

中国药物与临床
2012年 第8期

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