摘要
目的探讨贝前列素钠联合厄贝沙坦方案治疗糖尿病肾病的疗效。方法糖尿病肾病患者60例,在降糖、调脂、饮食控制等标准治疗的基础之上给予贝前列素钠40μg口服每天3次和厄贝沙坦150mg口服每天1次,治疗6个月,比较治疗前后血糖、血压、血脂、肾功能指标的变化。结果治疗前后血糖、血压、血脂差异无统计学意义(P>0.05),而反应肾功能变化的指标均有明显改善(P<0.05)。结论贝前列素钠联合厄贝沙坦是治疗糖尿病肾病的有效方法,具有独立的肾脏保护作用。
Objective To investigate therapeutic effect of combination of beraprost sodium with irbesartan on diabetic nephropathy. Methods 60 patients with diabetic nephropathy were included in this study. All the patients re- ceived the combination treatment of beraprost sodium 40 μg tid with irbesartan 150 mg qd for 6 months besides the standard background treatment of lifestyle change, hypoglycemia and lipid control. The changes of blood sugar, blood pressure,tipids and renal function indices were examined before and after treatment. Results After treated by iber- sartan and beraprost sodium, the levels of blood glucose, blood pressure, blood lipids were not statistically changed （P 〉0.05）. However, the indices reflecting renal function were significantly improved （P〈 0. 05）. Conclusion The combination treatment of beraprost sodium with irbesartan is an effective strategy for diabetic nephropathy, which can have independent renoprotective effect.
出处
《检验医学与临床》
CAS
2012年第15期1840-1841,共2页
Laboratory Medicine and Clinic
