痛风清冲剂对痛风性关节炎患者血脂与血液流变学影响的临床研究

Clinical Research of Tongfenqing Powder Preparation for Infusion on Blood Lipid and Hemorheology for Gouty Arthritis

目的观察痛风清冲剂对痛风性关节炎患者血脂与血液流变学的影响,探讨其治疗痛风性关节炎的作用机制。方法选取诊断为痛风性关节炎患者75例,随机分为两组。治疗组39例服用痛风清冲剂治疗,对照组36例服用别嘌醇片,两组均治疗1个疗程(4周);分别对两组患者治疗前后的血脂、血尿酸、血沉、CRP及血液流变学进行检测并进行比较。结果治疗组治疗后血脂、血尿酸、血沉、C反应蛋白(CRP)及血液流变学指标较治疗前均显著降低(P<0.01);与对照组治疗后比较差异有统计学意义(P<0.01)。结论通风清冲剂能有效治疗痛风性关节炎,可能与其能明显改善患者血脂、血尿酸、血沉、CRP及血液流变学多项指标有关。

Objective To observe the impacts of tongfengqing powder preparation for infusion on blood lipid and hemorheology for the patients with gouty arthritis and explore the mechanism of it in the treatment of gouty arthritis.Methods 75 cases of gouty arthritis were selected and randomized into two groups.In a treatment group（39 cases）,tongfengqing powder preparation for infusion was provided.In a control group（36 cases）,allopurinol tablets were prescribed.Either group was treated for one session（4 weeks）.The blood lipid,blood uric acid,erythrocyte sedimentation rate（ESR）,C-reactive protein（CRP）and hemorheology were detected and compared before and after treatment in two groups.Results After treatment,the levels of blood lipid,blood uric acid,ESR,CRP and hemorheology were all reduced significantly as compared with those before treatment（P〈0.01）.The statistical significant differences presented in comparison with the control group（P〈0.01）.Conclusion Tongfengqing powder preparation for infusion treats effectively gouty arthritis,which is probably related to the obvious improvements in blood lipid,blood uric acid,ESR,CRP and hemorheology.