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加味逍遥丸联合帕罗西汀对2型糖尿病伴焦虑者主观幸福感的干预作用 被引量:2

The influences of paroxetine modified Xiaoyao pill therapy on subjective well-beingfor type 2 diabetes patients with anxiety
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摘要 目的探讨加味逍遥丸联合帕罗西汀对2型糖尿病伴发焦虑患者在焦虑、糖代谢及主观幸福感方面的影响。方法选择2008年1月至2010年12月在首都师范大学社区卫生服务中心、北京宣武医院等多家医疗机构就诊的60例2型糖尿病伴发焦虑患者,按登记顺序随机分为两组各30例。治疗组予加味逍遥丸合帕罗西汀口服,对照组口服单纯帕罗西汀。观察治疗前后糖化血红蛋白(HbAlc)水平、特质焦虑量表(TAI)评分、纽芬兰纪念大学主观幸福感量表(MUNSH)评分的变化,观察时间为6周。结果治疗组与对照组患者治疗后TAI评分[分别为(38.89±6.70)分、(45.29±6.55)分]均较同组治疗前[分别为(54.07±6.41)分、(56.33±6.01)分]明显下降护〈0.05),且治疗组治疗后评分优于对照组(P〈0.05);HbAlc水平组内及组间比较[治疗后分别为(8.21±2.07)%、(7.92±1.90)%;治疗前分别为(8.14±2.69)%、(8.07±2.11)%]均无明显变化(P〉0.05);治疗组治疗后MUNSH评分[(44.53±6.28)分]较同组治疗前[(40.49±5.22)分]明显提高(P〈0.05),且与对照组治疗后(57.56±6.39)分,比较,差异有统计学意义(P〈0.05)。结论加味逍遥丸联合帕罗西汀可明显降低患者的焦虑程度,提高主观幸福感。 Objective To explore the influence of integrated Chinese and western medicine therapy on anxiety, sugar metabolism and subjective well-being for type 2 diabetes Patients associated with anxiety. Methods Use glycated hemoglobin (HbAlc), trait anxiety inventory(TAI), and Memorial University of Newfoundland Scale of Happiness (MUNSH) to evaluate the condition of 60 patients with type 2 diabetes associated with anxiety. The patients participated in the study were randomly divided into Western medicine therapy group(control group)and integrated traditional Chinese and Western medicine therapy group (experimental group), with 30 cases in each group. The control group was treated with paroxetine while the experimental group was treated with paroxetine plus Jiawei-Xiaoyaowan. 6 weeks after treatment, we tested the HbA 1 c level. TAI score and MUNSH score of those patients. Results After 6 weeks, the TAI score of patients in both experimental group and control group have obviously decreased (before treatment: 54.07±6.41 and 56.33±6.01, respectively; after treatment: 38.89±6.70 and 45.29±6.55, respectively) and the difference was statistically significant (P〈0.05). And the TAI score of the two groups after treatment was significantly different (P〈0.05). For both experimental and control groups, the HbAlc level were not obviously changed before and after the study with P〉0.05 (before treatment: 8.14±2.69 and 8.07±2.11, respectively; after treatment: 8.21 ±2.07 and 7.92± 1.90, respectively). Comparison between groups also showed no significant difference. MUNSH score have obviously increased in experimental group (before treatment: 40.49± 5.22; after treatment: 44.53± 6.28, P〈0.05). The result of comparison between the two groups after treatment shows that MUNSH score of patients in the experimental group were obviously improved compared with patients in the control group (57.56 ± 6.39), and the difference was statistically significant (P〈0.05). Conclusion The integratedtraditional Chinese and western medicine therapy can obviously release anxiety and enhance subjective well-being in patients with cerebral infarction associated with anxiety.
出处 《国际中医中药杂志》 2012年第8期689-691,共3页 International Journal of Traditional Chinese Medicine
关键词 2型糖尿病 焦虑 糖化血红蛋白 主观幸福感 Type 2 diabetes Anxiety Glyeated hemoglobin Subjective well-being
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