期刊文献+

脂联素在妊娠糖尿病发病中的临床意义 被引量:10

Serum adiponectin changes and its role in women with gestational diabetes mellitus
下载PDF
导出
摘要 目的探讨孕期脂联素(ADP)水平变化与妊娠糖尿病(GDM)血脂代谢指标及GDM发病的关系。方法选取GDM患者及正常对照组各60例,采用体外放射免疫分析方法测定其血清ADP、空腹胰岛素(FINS)水平,同时测定空腹血糖(FBG)、各项血脂水平总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C),计算稳态模型胰岛素抵抗指数(Homeostasis Model Assessment-Insulin Resistance,HOMA-IR),并测量身高、体质量,计算体质量指数(BMI)。结果血清ADP浓度在GDM组明显低于正常对照组,(5.8±0.6)mg/L vs(8.6±1.1)mg/L(P<0.01);GDM组的HOMA-IR、FINS、FBG、TG、LDL-C、TC均显著高于对照,5.4±1.2vs 2.8±0.7,(18.8±3.1)mU/L vs(13.6±2.2)mU/L,(6.5±0.9)mmol/L vs(4.6±0.7)mmol/L,(2.5±0.7)mmol/L vs(1.7±0.6)mmol/L,(3.2±0.7)mmol/L vs(2.3±0.5)mmol/L,(5.6±1.0)mmol/L vs(4.2±0.6)mmol/L。Pearson相关分析表明ADP水平与HOMA-IR、FBG、FINS及TG呈显著负相关。结论 ADP水平与胰岛素抵抗、高TG血症密切相关,低血清ADP水平参与了GDM的发生。 Objective To investigate the relation between serum adiponectin level,gestational diabetes mellitus(GDM) and blood lipid metabolism indices.Methods Radioimmunoassay was used to measure serum adiponectin levels of 60 woman with GDM and 60 cases of normal glucose tolerance group(NGT).Insulin,serum glucose,lipid and insulin resistance index were also measured and calculated.Results The level of adiponectin was significantly decreased in GDM group compared with that of NGT group,(5.8±0.6) mg/L vs(8.6±1.1) mg/L(P〈0.01).The levels of HOMA-IR,FINS,FBG,TG,LDL-C,TC were significantly increased in GDM group compared with those of NGT group,5.4±1.2 vs 2.8±0.7,(18.8±3.1) mU/L vs(13.6±2.2) mU/L,(6.5±0.9) mmol/L vs(4.6±0.7) mmol/L,(2.5±0.7) mmol/L vs(1.7±0.6) mmol/L,(3.2±0.7) mmol/L vs(2.3±0.5) mmol/L,(5.6±1.0) mmol/L vs(4.2±0.6) mmol/L.Significant negative correlation was found between the level of adiponcetin with HOMA-IR,FBG,FNS and TG.Conclusion Adiponectin plays an important role in monitoring the patients of GDM.Lower adiponectin is one of the main risk factors in predicting and screening of GDM.
出处 《临床荟萃》 CAS 2012年第16期1386-1388,共3页 Clinical Focus
基金 河北省科技支撑计划(10206126D)
关键词 糖尿病 妊娠 脂联素 胰岛素 放射免疫测定 diabetes,gestational; adiponectin; insulin; radioimmoassay
  • 相关文献

参考文献7

二级参考文献57

共引文献95

同被引文献73

  • 1周桂菊,陶瑞雪,李新玲,郑重,牛玉伟.妊娠期糖尿病孕妇新生儿脐血脂联素水平及其与胎儿生长发育的相关性研究[J].中华临床医师杂志(电子版),2011,5(17):4971-4975. 被引量:7
  • 2李红辉,唐平,丁殊节,王志毅,徐强(编校).妊娠期糖尿病患者血清脂联素和TNF-α浓度的检测及与胰岛素抵抗关系研究[J].中国妇幼保健,2007,22(7):921-923. 被引量:5
  • 3余丽金,冯玲.妊娠期糖尿病患者血清脂联素水平测定及意义[J].中国妇幼保健,2007,22(17):2319-2321. 被引量:2
  • 4Miehle K,Stepan H,Fasshauer M. Leptin, adiponec- tin and other adipokines in gestational diabetes melli- tus and pre - eclampsia[J]. Clin Endocrinol (Oxf), 2012,76(1) :2 - 11.
  • 5中华医学会糖尿病学分会.中国2型糖尿病防治指南(2010年版)[J].中华糖尿病杂志,2010,2增刊2:1-56.
  • 6Yokoyama H, Saito S, Daitoku K,et al. Effects of prava-statin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease [ J 1. Fundamental & Clinical Pharmacology, 2011,25 ( 3 ) : 16 - 18.
  • 7Pan J, Zhang F, Zhang L, et al. Influence of insulin sensitivi- ty and secretion on glycated albumin and hemoglobin Alc in pregnant women with gestational diabetes mellitus[J] Int J Gynaecol Obstet,2013 ,121(3) :252-256.
  • 8Hiramatsu Y, Shimizu l, Omori Y, et 1. Determination of reference intervals of glycated albumin and hemoglobin Alc in healthy pregnant Japanese women and analysis of their time courses and influencing factors during pregnancy[J]. Endocr J,2012,59(2):145-151.
  • 9Kohzuma T,Koga M. Lucica GA-L glycated albumin as say kit: a new diagnostic test for diabetesmellitus[J]. Mol Diagn Ther,2010,14(1) :49-51.
  • 10Han Y, Zheng YL, Fan YP, et al. Association of adiponec- tin gene polymorphism 45TG with gestational diabetes mellitus diagnosed on t. he new IADPSG criteria, plasma adi ponectin levels and adverse pregnancy outcomes [J]. Clin Exp Med,2014.

引证文献10

二级引证文献32

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部