^(99m)Tc-DTPA气溶胶显像测定呼吸道粘液纤毛清除功能

The Measurement of Tracheo-Bronchial Mucociliary Clearance by Techuetium-99m DTPA Aerosol Scintigraphy

为进一步研究呼吸道疾病时的粘液纤毛清除功能，采用99mTc－DTPA气溶胶吸入显像，通过电影显示定性和定量指标分析。对18例健康受试者和患者进行了显像研究，得到气道清除率和粘液纤毛清除率的正常值，并观察了32例慢性阻塞性肺病（COPD）患者气管-支气管纤毛清除功能的改变。结果显示，健康受试者与COPD患者粘液纤毛清除率（mm／min）分别为3．89±0．92和1．32±0.59，两者比较有显著性差异（P＜0．01），COPD患者不同时间气道清除率和粘液纤毛清除率均明显低于健康受试者（P＜0．01）。本研究方法简便客观，具有定性观察和定量分析的优点，对于呼吸系统其它疾病（如支气管扩张、原发性纤毛无运动）的研究及药物疗效的评价具有重要的临床实用价值。

Mucociliary clearance of respiratory channels is one of the important mechanisms guarding against retention of foreign particles within the lungs. Thus objective assay of the system is essential to recognizing and understanding its abnormalities. In this study, 18 healthy subjects and 32 patients with chronic obstructive pulmonary diseases (COPD) were examined by technetium-99m-DTPA aerosol scintigraphy. Monitoring was performed by visual inspection (cinescintigraphy) and quantitative analysis. The mucociliary clearance rates of 18healthy subjects and 32 COPD patients were 3. 89±0. 92 mm/min and 1. 32 ±0. 59 mm/min respectively.Statistical analysis indicated that the airway clearance rate and mucociliary clearance rate of COPD patients were significantly lower than those of normal subjects (P<0. 01). The method of assay reported here is simple and objective. It has not only the advantage of visual inspection and quantitative analysis, but also the potential usefulness in studying other bronchial diseases and evaluating therapeutic effectiveness of drugs.