胃癌细胞DNA含量与淋巴结转移关系的初步研究

The Relations of Cellular DNA Content to Lymph Node Metastasis in Gastric Carcinoma

应用流式细胞术研究胃癌细胞DNA含量、S期细胞比率（SPF）和G2／M期细胞比率（G2／MPF）与胃癌淋巴结转移的关系。结果显示：异倍体胃癌淋巴结转移率及SPF显著高于二倍体胃癌（P＜0.05）。淋巴结转移个数越多，转移距离越远，也常发生在异倍体瘤。而G2／MPF则与淋巴结转移无明显关系。以上结果表明：胃癌细胞DNA含量、SPF与淋巴结转移个数、转移距离有一定关系。

The objectives of this study were to evaluate the relations of cellular DNA content, S-phase fraction (SPF) and G2/M-phase (G2/MPF) to lymph node metastasis in gastric carcinoma by using flow cytometry.The results showed that the incidence of lymph node metastasis and SPF were significantly higher in aneuploid carcinoma than in diploid carcinoma (P <0.05). But the G2/MPF values did not corre1ate with lymph node metastasis. These findings suggest that correlations between cellular DNA content, SPF and the extent of lymph node metastasis are present.