外阴营养不良和恶性肿瘤与雌、孕激素受体关系的研究

Relationship Between Vulvar Dystrophy, Malignant Tumor and the Estrogen Progestin Receptor

为了探讨雌、孕激素受体与外阴营养不良、恶性肿瘤的关系，用葡聚糖-活性碳单点饱和分析法测定了31例外阴营养不良（增生型14例、混合型10例、萎缩型7例）和19例外阴恶性肿瘤（外阴鳞形细胞癌16例）的雌、孕激素受体（ER、PR）含量。结果：ER的含量混合型高于萎缩型，PR的含量混合型高于增生型，增生型高于萎缩型（P值均＜0．05）；外阴营养不良及其邻近正常组织的ER与PR的含量之间呈正相关关系（P＜0．01），外阴鳞状细胞癌PR的含量随分化程度的降低而逐渐降低，且癌组织PR含量明显低于其邻近的正常组织。以上结果为外阴营养不良的内分泌治疗提供了理论依据，在外阴恶性肿瘤中，PR可作为判断预后的指标之一。

In order to investigate the relationship between vulvar dystrophy, malignant tumor, and estrogen,progestin receptor, we made an analysis on estrogen and progestin receptor (ER, PR) contents in 31 cases of vulvar dystrophy and 19 cases of malignant tumor, using the dextran-coated charcoal method. The Results showed that ER content of the mixed type was higher han that of the atrophic type. PR content of the mixed type was higher than that of the hyperplastic type; and the PR content of the hyperplastic type was higher than that of the atrophic type. The relationship between ER and PR contents of the vulvar dystrophy and adjacent normal tissue was in positive correlation. The PR content of vulvar squamous cell carcinoma went down along with the drop of its dedifferentiation degree. The PR content of carcinoma was much lower than that of the adjacent normal tissue.The results of suggest that the study provided theoretic basis for endocrinotherapy of the vulvar dystrophy, PR in malignant tumor is regarded as one of the indexes to predict prognosis.