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HMGB1半胱氨酸残基氧化还原状态与其功能 被引量：1

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摘要 高迁移率族蛋白1（High Mobility Group box 1,HMGB1）是一种非组蛋白核蛋白,在许多疾病中发挥重要作用.现有越来越多的研究表明HMGB1 蛋白第106位点上半胱氨酸残基的氧化还原状态与其功能特性密切相关. 1 HMGB1的结构与功能 高迁移率蛋白（High Mobility Group,HMG）是一组非组蛋白核蛋白,广泛表达于真核生物细胞中,早于20世纪60年代由细胞核中提纯获得,经过几十年的发展又分为几大家族,高迁移率族蛋白1（High Mobility Group Box 1,HMGB1） 是HMG超家族中的一员.
作者 陈岩 秦阳华 沈茜
机构地区 第二军医大学附属长海医院实验诊断科
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2012年第7期662-665,共4页 Chinese Journal of Immunology
基金 国家自然科学基金项目资助(31000395)
关键词 HMGB1 氧化还原状态 半胱氨酸 高迁移率族蛋白 残基 真核生物细胞 非组蛋白 功能特性
分类号 R392.11 [医药卫生—免疫学]
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参考文献20

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同被引文献31

  • 1Asavarut P, Zhao H, C.u J, et al, The role of HMGB1 in inflammation- mediated organ injury[J]. Acta Anaesthesiol Taiwan, 2013, 51 ( 1 ) : 28 - 33.
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  • 3Kang R, Tang D, Livesey KM, et al. The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury[J]. Antioxid Redox Signal, 2011, 15(8 ) : 2175 -2184.
  • 4Kang R, Tang D, Schapiro NE, et al. The I-IMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics [ J ]. Oncogene, 2014, 33 (5) : 567 - 577.
  • 5Yang H, Antoine DJ, Andersson U, et al, The many faces of HMGBI: molecular structure-functional activity in inflammation, apoptosis, and chcmotaxis[J]. J Leukoc Biol, 2013, 93(6) : 865 - 873.
  • 6Antoine DJ, Williams DP, Kipar A, et al, Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hcpatotoxicity [ J ]. Mol Med, 2010, 16(11/12) : 479-490.
  • 7Janko C, Filipovic M, Munoz LE, et al, Redox modulation of HMGBl-related signaling [ J ]. Antioxid Rodox Signal, 2014, 20 (7) : 1075 - 1085.
  • 8Tang D, Billiar TR, Lotze MT. A Janus tale of two active high mobility group box 1 (HMGB1) redox states[J/OA]. Mol Med, 2012, 18: 1360 - 1362.
  • 9Yang H, Hreggvidsdottir HS, Palmblad K, et al, A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrephage cytokine release [ J ]. Prec Natl Acad Sci U S A, 2010, 107(26): 11942-11947.
  • 10Schiraldi M, Raucei A, Munoz LM, et al, HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling v/a CXCR4 [J]. J Exp Med, 2012, 209 (3) : 551 -563.

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中国免疫学杂志
2012年 第7期

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