2Tanaka M.Pharmacological and clinical profile of the free radical scavenger edaravone as a neuroprotective agent[J] . Nippon Yakurigaku Zasshi, 2002, 119(5):301.
3Edaravone Acute Infarction Study Group.Effect of a novel free radical scavenger,edaravone (MCI- 186),on acute brain infarction .Randomized, placebo- controlled,double - blind study at multicenters[J ]. Cerebrovasc Dis,2003,15(3): 222.
5Toshiaki Watanabe, Mitsuo Egawa.Effects of an antistroke agent MCI - 186 on cerebral arachidonate cascade[J ]. The J. of Pharmacol and Exp. Ther, 1994,271(3) ,1 624.
6Broshi Kawai,Hiroshi Nakai,Misao Suga,et al .Effects of a novel free radical scavenger. MCI - 186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model[J ] . The J. of Pharmacol and Exp. Ther, 1997,281(2), 921.
7Toshiaki Watanabe, Satoshi Yuki, Mitsuo Egawa, et al.Protective effects of MCI - 186 on cerebral ischemia: Possible involvement of free radical scavenging and antioxidant actions[J ]. The J. of Pharmacol and Exp.Ther, 1994,268(3), 1 597.
8Shibata Hisao,Arai Shigenori, Izawa Minae,et al. Phase Iclinical study of MCI- 186(edaravone, 3-methy-1 - phenyl - 2 - pyrazolin - 5 - one) in healthy volunteers: Safety and pharmacokinetics of single and multiple administrations[J ] .Jpn J Clin Pharmacol