急性脑梗死患者血清白细胞介素-6及白细胞介素-8和肿瘤坏死因子-α水平变化及临床意义

Levels of serum interleukin-6,interleukin-8 and tumor necrosis factor-α in patients with acute cerebral infarction

目的探讨急性脑梗死(ACI)患者血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)的水平变化及临床意义。方法 ACI组85例患者分为轻度组31例,中度组29例和重度组25例;另选择同期进行健康体检者40例作为对照组;采用酶联免疫吸附法测定血清IL-6、IL-8和TNF-α水平。结果 ACI组患者血清IL-6、IL-8和TNF-α水平显著高于对照组(P<0.05),重度组患者血清IL-6、IL-8和TNF-α水平显著高于轻度组和中度组(P<0.05),中度组患者血清IL-6、IL-8和TNF-α水平显著高于轻度组(P<0.05)。结论血清IL-6、IL-8和TNF-α水平升高可能与ACI的发生和发展有关,检测血清IL-6、IL-8和TNF-α水平有助于评估ACI患者的病情及预后。

Objective To explore the change and clinicial significance of the levels of serum interleukin-6 （IL-6） ,inter- leukin-8 （ IL-8 ） and tumor necrosis factor-α （TNF-α） in patients with acute cerebral infarction （ACI）. Methods Eighty-five patients with ACI of ACI group were divided into the mild group（ n = 31 ） , moderate group（ n = 29 ） and severe group （n = 25 ） ; at the same time ,forty healthy people were chose as control group. The levels of serum IL-6, IL-8 and TNF-α were detected with enzyme linked immunosorbent assay. Results The levels of serum IL-6, IL-8 and TNF-α in ACI group were significantly higher than those in control group（ P 〈 0.05 ）. The levels of serum IL-6, IL-8 and TNF-α in severe group were significantly higher than those in mild group and moderate group （ P 〈 0.05 ）. The levels of serum IL-6, IL-8 and TNF-α in moderate group were significantly higher than those in mild group （ P 〈 0.05 ）. Conclusion Serum IL-6, IL-8 and TNF-α levels increasing may be related with the occurrence and development of ACI. The detection of serum IL-6, IL-8 and TNF-α should be helpful to assess the severity and prognosis of patients with ACI.