横纹肌肉瘤的临床病理分析

PATHOLOGIC STUDY ON RHABDOMYOSARCOMA

目的 :探讨横纹肌肉瘤的诊断和鉴别诊断中免疫组织化学标记的意义及不同类型横纹肌肉瘤对预后的影响。方法 :应用病理形态学和免疫组化方法对 47例横纹肌肉瘤进行研究。结果 :47例横纹肌肉瘤中胚胎性 2 8例 ,腺泡状 16例 ,其中 7例伴广泛侵润、复发和转移 ,多型性 3例 ;结蛋白 (desm in)和肌球蛋白 (m yoglobin)的阳性率分别为 (89% )和 (83.2 % )。结论 和胚胎性横纹肌肉瘤相比 ,腺泡状横纹肌肉瘤具有更恶的临床生物学行为 ;desm

To search for the significance of immunohistochemical markers for the differential diagnosis of rhabdomyosarcoma and the clinical impact of different subtypes of rhabdomyosarcoma on prognosis. Method:Pathomorphological and immunohistichemical methods were used for study of 47 cases of rhahdomyosarcoma Results:Of the 47 cases,28 cases are embryonal rhabdomyosarcoma,16 cases of alveolar rhabdomyosarcoma,seven of whom were accompanied by extensive invasiveness,recurrence and metastasis,3 cases showed polymorphism,higher positive rates of desmin(89%)and myoblobin(83.2%) were found in rhabdomyosarcoma.Conclusion:The clinical behavior in alveolar rhabdomyosarcoma is more malign than that in embryonal rhabdomyosarcoma,desmin and myoglobin turned out to be a favorite markers for the differential diagnosis of rhabdomyosarcoma