复方桐叶烧伤油对细胞性皮肤溃疡模型大鼠的影响

Effect of compound Aleurites fordii Hemsl.leaf burn ointment on rat model of cellular skin ulcer

目的:研究复方桐叶烧伤油对皮肤溃疡的作用。方法:切割大鼠背部皮肤造成缺损皮肤伤口,再涂粪水细菌感染3天形成皮肤溃疡模型。然后经复方桐叶烧伤油治疗14天,测定大鼠创面面积,溃疡皮肤组织病理及TGF-α、TNF-β含量。结果:经复方桐叶烧伤油治疗14天后创面明显缩小,溃疡皮肤组织中的TGF-α含量升高,TNF-β含量降低;溃疡皮肤组织中肉芽组织厚度明显降低,炎症细胞数明显减少。结论:复方桐叶烧伤油对慢性皮肤溃疡有较好的治疗作用。

Objective： To study the effect of compound Aleurites fordii Hems1. leaf burn ointment on skin ulcer. Methods： The back skin of rats was cut to form wounds, and then excrement liquid was applied to infect the wounds with bacteria for 3 d and form a skin ulcer model. The rats with skin ulcer were treated with compound Aleurites fordii Hemsl. leaf burn ointment for 14 d. The area of wound surface as well as the pathology and TGF - o~ and TNF - ~ contents of ulcerative skin tissue were determined. Results ： After treatment with compound Aleurites fordii Hemsl. leaf burn ointment, the area of wound surface was decreased significantly; the TGF - ct content of ulcerative skin tissue was increased, while the TNF - [3 content was decreased ; the thickness of granulation tissue and the number of inflammatory cells in the ulcerative skin tissue were decreased significantly. Conclusion： Compound Aleurites fordii Hemsl. leaf burn ointment has good therapeutic efficacy in treatment of chronic skin ulcer.