摘要
【目的】通过检测血清总胆汁酸(TBA)水平,确立该指标在婴幼儿肝炎综合征诊治中的意义。【方法】采用全自动酶法分析技术对65例婴幼儿肝炎综合征患儿及65例正常对照的婴幼儿进行空腹血清总胆汁酸测定,同时对其他肝功能相关项目进行测定。【结果】正常对照婴儿血清总胆汁酸值呈正偏态分布,经对数转换后,D检验呈对数正态分布,参考值范围0~11.7μmol/L;肝炎综合征患儿测定结果为,血清总胆汁酸检测阳性率达89.2%,均值较正常上限升高7~10倍。与碱性磷酸酶(ALP)、直接胆红素(DBIL)及γ谷氨酰转移酶相比,具有显著的正相关,且血清总胆汁酸灵敏度和特异性明显优于以往的指标。【结论】血清总胆汁酸测定具有特异性强、灵敏度高及数值变化趋势稳定性的优势,可为婴幼儿肝炎综合征的诊断提供可靠的实验室依据。
[ Objective ] To determine the significance of serum total bile acid (TBA) in the diagnosis and treatment of infantile hepatitis syndrome. [Methods] Serum TBA and other liver function related items were deter-mined with automatic enzymatic assay techniques in 65 infants with infantile hepatitis syndrome patients and 65 normal infants. [ Results] In the control group, the serum TAB level was 0-11.7 μmol/L. TBA levelwas abnormal in 89.2% patients, the mean more normal limit rise 7 to 10 times. The difference was significant between the two groups. The TBA levelswere well-related. To those of ALP, DBIL and γ-GT and TBA was better than others in sensitivity and specificity. [Conclusions] Beil acids are specific strong determination, high sensitivity and numerical change trend the advantage of stability for the diagnosis of infant hepatitis syndrome to provide reliable basis for the laboratory.
出处
《武警医学院学报》
CAS
2012年第7期528-530,共3页
Acta Academiae Medicinae CPAPF