血清总胆汁酸测定在婴幼儿肝炎综合征治疗中的意义

Application of serum total bile acid determination in infantile hepatitis syndrome

【目的】通过检测血清总胆汁酸(TBA)水平,确立该指标在婴幼儿肝炎综合征诊治中的意义。【方法】采用全自动酶法分析技术对65例婴幼儿肝炎综合征患儿及65例正常对照的婴幼儿进行空腹血清总胆汁酸测定,同时对其他肝功能相关项目进行测定。【结果】正常对照婴儿血清总胆汁酸值呈正偏态分布,经对数转换后,D检验呈对数正态分布,参考值范围0～11.7μmol/L;肝炎综合征患儿测定结果为,血清总胆汁酸检测阳性率达89.2%,均值较正常上限升高7～10倍。与碱性磷酸酶(ALP)、直接胆红素(DBIL)及γ谷氨酰转移酶相比,具有显著的正相关,且血清总胆汁酸灵敏度和特异性明显优于以往的指标。【结论】血清总胆汁酸测定具有特异性强、灵敏度高及数值变化趋势稳定性的优势,可为婴幼儿肝炎综合征的诊断提供可靠的实验室依据。

[ Objective ] To determine the significance of serum total bile acid （TBA） in the diagnosis and treatment of infantile hepatitis syndrome. [Methods] Serum TBA and other liver function related items were deter-mined with automatic enzymatic assay techniques in 65 infants with infantile hepatitis syndrome patients and 65 normal infants. [ Results] In the control group, the serum TAB level was 0-11.7 μmol/L. TBA levelwas abnormal in 89.2% patients, the mean more normal limit rise 7 to 10 times. The difference was significant between the two groups. The TBA levelswere well-related. To those of ALP, DBIL and γ-GT and TBA was better than others in sensitivity and specificity. [Conclusions] Beil acids are specific strong determination, high sensitivity and numerical change trend the advantage of stability for the diagnosis of infant hepatitis syndrome to provide reliable basis for the laboratory.