老年Ⅱ型糖尿病胰岛素抵抗患者对子代影响的研究

A STUDY ON THE EFFECT OF AGED INSULIN RESISTANCE PATIENTS WITH TYPE Ⅱ DIABETES MELLITUS ON THEIR FILIAL GENERATION

目的 :探讨老年 型糖尿病 (NIDDM)胰岛素抵抗 (IR)患者对子代的影响。方法 :老年 型糖尿病 IR患者及其直系第 1代子女组与健康老年人及其直系第 1代子女组各 34例 ,分别检测体质量指数 (BMI)、空腹血糖 (SG)、胰岛素(In S)、 C肽 (CP)、胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白 (HDL- ch)、低密度脂蛋白 (L DL- ch)、血尿酸 (u A)、纤维蛋白原 (F)及餐后 2 h血糖 (SG2 )、胰岛素 (In S2 )、C肽 (CP2 ) ,并计算 In S/SG比值。胰岛素敏感指数 (IAI) ,胰岛素抵抗指数 (IRI)。结果 :老年 NIDDM及其子女组与健康老年人及其子女组对比 :SG、In S、In S2 、IAI、IRI、TC、TG有高度显著性差异 (P <0 .0 1) ,SG2 、 u A、 In S/SG有显著性差异 (P <0 .0 5 ) ,CP、L DL、 HDL、F两组对比无显著性差异(P >0 .0 5 )。结论 :老年 型糖尿病子代存在 IR现象 ,机体对胰岛素的敏感性降低 ,对胰岛素抵抗性增强。

Objective:To study the effect of aged insulin resistance patients with type Ⅱ diabetes mellitus (NIDDM) on their filial generation Methods:A group of 34 cases of aged insulin resistance patients with type Ⅱ diabetes mellitus and their first filial generation,was set up against another group of 34 cases good healthy aged and their first filial generation Examing body mass index (BMI),the fasting blood glucose (SG),Insulin (InS),C peptide (CP),the total cholesteral (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL ch),low density lipoprotein cholesterol (LDL ch),insulin (InS 2),C peptide (CP 2) hours after eating food Calculating InS/SG,insulin sensitive index (IAI),Insulin resistance index (IRI) Results:Contrasting the two groups,we found highly significant difference in SG InS,InS 2,IAI,IRI,TG and TC (P<0 01) There was significant difference in SG 2,uA and InS/SG (P<0 05) There was no significant difference in CP,LDL,HDL,and F(P>0 05) Conclusion:There was insulin resistance phen omenon in aged NIDDM's filial generation,body's sensitivity to insulin reduced but to insulin resistance strengthened