高聚金葡素对原发性肝癌患者TAE术治疗期间免疫水平的影响

EFFECT OF HIGHLY AGGLUTINATIVE STAPHYLOCOCCIN ON IMMUNE FUNCTION IN TREATMENT OF HEPATOMA WITH TAE

目的 :观察高聚金葡素 (HASL )对原发性肝癌患者 TAE治疗中免疫水平的影响。方法 :治疗组 2 2例 ,TAE术后每天皮下注射 HASL 5 0 0～ 10 0 0 IU,30 d为一疗程 ,对照组 18例仅行 TAE治疗。结果 :治疗后治疗组细胞免疫功能有所好转 ,对照组细胞免疫功能明显下降 ;但两组体液免疫无改变。治疗组疗效及 Karnofsky评分优于对照组。结论 :原发性肝癌患者行TAE时联合 HASL 治疗可有效地减免化疗对患者细胞免疫功能的抑制 ,能提高 TAE疗效及改善患者的生存质量。

Objective:To evaluate the effect of highly agglutinative staphylococcin (HASL) on immune function in treatment of hepatoma with TAE Methods:Forty patients (male 37,female 3) with hepatoma were randomly divided into two groups (Group Ⅰ 22 cases treated with HASL for 30 days in 500~1 000 IU each day after TAE,Group Ⅱ 18 cases treated only with TAE) Results:The cell immune function increased in Group Ⅰ (P>0 05) and decreased significantly in Group Ⅱ (P<0 05) The karnafsky score and the therapy effect were increased in Group Ⅰ Conclusions:Combination therapy of HASL and TAE can effectively prevent the decrease of cell immune and improve the life quality of patients and increase the therapy effect of TAE