摘要
了解没食子酰表没食子儿茶素 (EGCG)抗肿瘤作用。方法 :用小鼠肉瘤 180 (S- 180 )、小鼠肝癌 (Hep)为瘤株 ,对 EGCG进行体内外抗肿瘤药效试验和观察其对荷瘤小鼠免疫器官重量的影响。结果 :EGCG灌胃 80、 40 mg/ kg· d- 1 ,连续 7d,对小鼠移植性 S- 180实体瘤有明显抑制作用 ;80 m g/ kg· d- 1可延长 Hep腹水癌小鼠生命 ;16 0、 80、 40、 2 0 mg/ L的 EGCG对 S- 180和 Hep瘤细胞的体外存活有明显抑制 ;16 0、 80、 40、 2 0、 10 m g/ L 的 EGCG可完全或部分灭活 Hep瘤苗 ;除 10 m g/ L 浓度组外 ,其余各浓度组亦可部分灭活 S- 180瘤苗 ;80、 40 m g/ kg可增加荷瘤小鼠胸腺重量。结论 :EGCG在实验条件下有一定抗肿瘤作用 ,能延缓免疫器官衰退。
Objective:The purpose of this study was to understand the anti tumor effect of (-) epigallocatechin gattate,EGCG Methods:The pharmacodynamic test of EGCG on sarcoma 180(S 180) hepato cacinoma (Hep)in mice or in vitro and the effect of EGCG on the weight of immunic organ of mice implanted tumor were observed Results:The finding showed that the growth of transplanted S 180 was significantly inhibited and that the lifetime of mice with Hepascitic carcinoma could be prolonged when EGCG were administered intragastioly to mice for 7days EGCG could significantly inhibited the living cells of S 180 and Hep in vitro and decrease the rate of implant on tumor cells to mice In addition,EGCG could also increase the weight of thymus in mice with tumor Conclusion:These results suggested that EGCG have antitumor effect and can delay immunic organ failure
出处
《广西医科大学学报》
CAS
2000年第2期176-179,共4页
Journal of Guangxi Medical University
基金
广西区科技厅科学研究与技术开发课题! (桂科攻 98170 91)
