自体瘤苗回植对恶性黑色素瘤患者免疫功能的影响

EFFECT OF AUTO-TUMOUR VACCINE REPLANTATION ON THE IMMUNICAL FUNCTION OF MALIGNANT MELANOMA PATIENTS

观察自体瘤苗回植对恶性黑色素瘤患者免疫功能的影响。方法 :用 S- P一步法及免疫浊度法分别检测 30例恶性黑色素瘤患者自体瘤苗回植前后 NK细胞活性、 CD3、 CD4、 CD8、 CD4/CD8及 Ig A、 Ig G、 Ig M的水平 ,并比较其变化。结果 :治疗后 NK细胞活性、 CD3、 CD4、 CD4/CD8及 Ig G水平均显著升高 (P <0 .0 5 ) ,而 CD8、 Ig A、 Ig M无显著变化 (P >0 .0 5 )。结论 :自体瘤苗回植后能改善恶性黑色素瘤患者的免疫功能 ,尤以细胞免疫功能改善显著。

Objective:To observe the effect of auto tumour vaccine replantation on the immunical function of malignant melanoma patients Methods:Thirty cases of malignant melanoma were treated with auto tumour vaccine replantation,measured the ratio of the NK cell activity,T lympocyte subpopulation and the content of the immunoglobulin in blood before and after the treatment and compared the changes Results:The ratio of the NK cell activity,the CD 3 and CD 4 subpopulation of the T lympocyte,CD 4/CD 8 rate and the content of the IgG rose significantly after the treatment (P<0 05) Conclusion:The results indicated that auto tumour vaccine replantation could enchance the immunical function,especially the cell immunical function of malignant melanome patients