肿瘤患者血清sIL-2R水平变化的临床意义

CLINICAL SIGNIFICANCE OF SERUM sIL-2R LEVEL IN TUMOR PATIENTS

观察肿瘤患者血清可溶性白细胞介素 2受体 (s IL- 2 R)水平的变化及临床意义。方法 :采用双抗体夹心 EL ISA法对 40例正常人、 30例良性肿瘤及 180例恶性肿瘤患者的血清 s IL- 2 R水平进行测定。结果 :1正常人和良性肿瘤患者血清 s IL-2 R水平较低 ,恶性肿瘤患者明显升高 ,与正常人及良性肿瘤患者比较均有极显著性差异 (P <0 .0 0 1) ;2 s IL- 2 R水平与临床分期及病情严重程度有关 ,处于 、 期的肿瘤患者血清 s IL- 2 R水平显著高于 、 期肿瘤患者 (P <0 .0 1) ;3 6 5例恶性肿瘤患者经手术切除及综合治疗后血清 s IL- 2 R水平较术前明显下降 (P <0 .0 5 )。结论 :恶性肿瘤患者血清 s IL- 2 R水平明显高于正常人及良性肿瘤患者 ,并与病情发展和转归密切相关。

Objective:To observe the changes and clinical significance of the serum sIL 2R level in tumor patients Methods:The level of serum sIL 2R was determined by ELISA method in 40 healthy controls,30 patients with benign tumor and 180 patients with malignant tunor Results:①The level of serum sIL 2R of patients with malignant tumor was significantly higher than that of patients with benign tumor and that of healthy controls (P<0 001);②The serum sIL 2R level correlated with clinical stage and degree of disease,the tumor patients in the stage Ⅲ and Ⅳ had higher sIL 2R level than those who in the stageⅠand Ⅱ;③The level of serum sIL 2R of 65 patients with malignant tumor decreased markedly after treatment with operation,radiotherapy,chemotherapy and biotherapy (P<0 05) Conclusion:The level of serum sIL 2R of patients with malignant tumor was higher than that of healthy controls and that of patients with benign tumor,and correlated with the development of the diseases The level of serum sIL 2R can be used as a useful clinical indicator to diagnose,evaluate the theropeutic effect and assess prognosis