外周动脉疾病患者踏车运动干预疗效的临床研究

Peripheral Artery Disease Patients Who Exercise Treadmill Intervention Curative Effect of Clinical Research

目的：研究踏车运动对外周动脉疾病（peripheral arterial disease,PAD）患者功能恢复及远期预后的影响。方法：选取2010年5月~2011年4月于我院（50例）、遵义医学院附属医院（30例）、湖南省湘乡市人民医院（40例）心血管内科就诊的PAD患者共120例,并将其随机分为研究组和对照组。研究组实施6个月踏车运动运动干预,对照组则不接受,并分别于开始前及结束后记录踏车运动表现以及肱动脉流量介导的血管内皮功能等指标,其它PAD常规药物治疗两组相同。结果：（1）实施踏车运动干预6个月后,与对照组相比：研究组6分钟步行距离有显著增加（P〈0.01）;患者能够耐受的最长踏车时间及距离显著增加（P〈0.01）;肱动脉血流介导内皮舒张功能（FMD）显著改善（P〈0.01）。结论：踏车运动干预可增加6分钟步行距离;延长最长踏车时间和距离;改善肱动脉血流介导的血管内皮功能。

Objective：Research exercise treadmill foreign weeks artery disease（peripheral arterial disease,PAD） patients function recovered,the influence of the long-term prognosis.Methods：Selection in May 2010-April 2011 in our hospital（50 cases）,zunyi medical school affiliated hospital（30 cases）,hunan province the xiangxiang people’s hospital of 40 patients of cardiovascular medicine clinic of PAD with a total of 120 patients,and the divided into research group and the control group.The team implemented six months to exercise treadmill motion intervention,the control group is not acceptable,and separately in the day before and after exercise treadmill record performance and humerus artery flow mediated endothelial function index,other PAD conventional treatments two groups of the same.Results：（1） implementation exercise treadmill intervention in six months,compared with the control：the team 6 minutes walking distance increased significantly（P〈0.01）;Patients were able to tolerate the longest treadmill time and distance increased significantly（P〈0.01）;Humerus artery flow mediated dilation（FMD） endothelial improved significantly（P〈0.01）.Conclusion：Exercise treadmill intervention can increase 6 minutes walking distance;Extend the longest treadmill time and distance;Improve the brachial artery flow mediated vascular endothelial function.