米索前列醇不同给药途径应用于人工流产术的临床分析

Different Routes of Administration of Misoprostol used in the Clinical Analysis of Induced Abortion

目的：观察对人工流产术后患者予以不同的给药途径使用米索前列醇治疗的临床效果,并探讨最佳的给药方式。方法：对我院自2006年11月~2011年11月以来,于我科治疗的人工流产术后妊娠妇女360例临床资料进行回顾性分析,将其随机分成三组,Ⅰ组（口服）120例,Ⅱ组（阴道放置）120例,Ⅲ组（舌下含服）120例,Ⅰ组患者在进行人工流产术之前的3小时应用400μg的米索前列醇空腹顿服,Ⅱ组患者在术前的3小时经妇科医师操作,将已被生理盐水进行湿化后的400μg米索前列醇阴道放置。Ⅲ组患者在术前的3小时由医生指导将400μg的米索前列醇舌下含服。结果：对全部患者的手术时间与手术出血量进行比较,均不具有明显差异（P〉0.05）;而宫口松弛的程度具有显著性的差异,Ⅲ组患者显效率与有效率均明显高于Ⅰ、Ⅱ两组（P〈0.05）;Ⅱ组患者发生阴道出血与腹痛的情况均明显多于Ⅰ、Ⅲ两组（P〈0.05）,Ⅰ组患者的胃肠道反应比较明显。结论：对人工流产术患者应用米索前列醇能够有效扩张其宫颈,予以舌下含服后患者宫口的松弛度良好,并且能够避免由于口服及阴道给药所引起相关的副反应,应作为临床首选的给药方式。

Objective：Observation of patients after abortion to be a different route of administration used the clinical effect of misoprostol treatment,and to explore the best mode of administration.Methods：Our hospital from November 2006 to November 2011 has been treated in our department after abortion pregnant women 360 cases were retrospectively analyzed clinical data were randomly divided into three groups,Ⅰ group（oral） 120 cases,group Ⅱ（vaginal） 120 cases,Ⅲ group（sublingual） 120 cases,Ⅰ patients before abortion during three hours of application of 400μg of misoprostol fasting Dayton clothing,Ⅱ group of patients in the preoperative 3 hours after gynecological physician,would have been after normal saline wet vaginal misoprostol 400μg.Patients in group Ⅲ 3 hours before surgery by a doctor to guide the 400μg of misoprostol sublingually.Results：The time of surgery all patients were compared with surgical blood loss,not a significant difference（P〉0.05）;and the degree of relaxation of the cervix with a significant difference,Ⅲ group of patients was significantly higher than the efficiency and the effective rate of Ⅰ, two groups（P〈0.05）;Ⅱ group of patients with vaginal bleeding and abdominal pain significantly more than the case Ⅰ,Ⅲ two groups（P〈0.05）,Ⅰ gastrointestinal tract in patients obvious.Conclusion：For patients with misoprostol induced abortion can effectively expand its cervical,sublingual be patient after a good degree of relaxation of the cervix,and can avoid the cause of oral and vaginal administration related side effects,should be preferred as a clinical mode of administration.