替勃龙联合更美宁胶囊治疗围绝经期综合征临床观察

Clinical Research on Treating Menopausal Syndrome by Tibolone Combined with Gengmeining Capsules

目的:观察替勃龙(利维爱)联合更美宁胶囊治疗围绝经期综合征的临床疗效。方法:将110例患者随机分为治疗组及对照组。两组采用相同的基础治疗,对照组口服尼尔雌醇及安宫黄体酮。治疗组予利维爱及更美宁胶囊。两组均以3个月为1个疗程。结果:总有效率治疗组92.72%,优于对照组80.00%(P<0.05);两组对卵泡刺激素、黄体生成素和雌二醇具有相似的调节作用,但治疗组在降低临床症状积分方面更具优势;治疗后治疗组TG、TC、LDL-c均较治疗前显著降低(P<0.05),与对照组比较亦有显著性差异(P<0.05)。结论:利维爱联合更美宁胶囊治疗围绝经期综合征疗效确切,作用安全,值得推广。

Objective：To observe the clinical effect of tibolone combined with Gengmeining Capsules on the treatment of Menopausal Syndrome.Methods：110 cases of Menopausal Syndrome were randomly divided into two groups.Two groups used the same basic therapy.Patients in the control group were treated with Neil female alcohol and Ann palace progestin.The treatment group were treated by tibolone combined with Gengmeining Capsules.The clinical efficacy was evaluated after two cycles of chemotherapy.A course of treatment was 3 months.Results：The total effective rate of the treatment group 92.72%,better than control group80.00%（P〈0.05）;There were similar regulatory role between two groups Including Follicle-stimulating hormone,corpus luteum erythropoietin and estradiol,but the treatment group in reducing the clinical symptom scores more advantages;The TG,TC,LDL-c in the treatment group significantly decreased after treatment（P〈0.05）,compared with controls also significant difference（P〈0.05）.Conclusion：Tibolone combined with Gengmeining Capsules is a relatively safe and efective regimen for patients with Menopausal Syndrome,is worthy to be popularized.