复方二氯醋酸二异丙胺联合复方甘草甜素对慢性乙型肝炎的协同效应研究

The Clinical Cooperativity of Diisopropylamine Dichloroacetate Plus Stronger Neo-Miaophagen in Treatment with Chronic Hepatitis

目的:观察复方二氯醋酸二异丙胺联合复方甘草甜素治疗慢性乙型肝炎是否具有临床协同效应。方法:将366例慢性乙型肝炎患者随机分为治疗组和对照组A,B,前者给予复方二氯醋酸二异丙胺联合复方甘草甜素治疗,与单用复方二氯醋酸二异丙胺治疗和单用复方甘草甜素加安慰剂治疗分别为对照组A,B。观察症状、体征,治疗前后检测乙型病毒性肝炎血清学定量指标与HBV DNA,治疗过程中定期监测肝功能、肾功能及电解质。结果:联合给药治疗后显效率(61.24%vs 34.19%vs19.44%),ALT(42.03±15.28)vs(54.63±39.28)vs(56.72±36.28),AST(46.25±21.45)vs(63.85±45.95),TBIL(17.05±10.63)vs(32.25±31.45)vs(29.37±32.90)下降程度,肝功复常时间(29.85±23.85)d vs(39.27±19.99)d vs(40.06±20.85)均优于对照组A,B,具有统计学差异(P<0.05)。另外联合给药组ALT反跳率(3.8%vs 18.8%vs20%),AST反跳率(4.6%vs 20.5%vs 21.7%)低于对照组A,B并具有统计学差异(P<0.05)。治疗过程中联合用药并不增加单药的副作用。结论:复方二氯醋酸二异丙胺联合复方甘草甜素治疗慢性乙型肝炎具有协同效应,能进一步提高单药应用疗效,并缩短治疗疗程,且并不增加单药副作用。

Objective：To study the clinical cooperativity of diisopropylamine dichloroacetate plus Stronger Neo-Miaophagen in treatment with chronic hepatitis.Methods：Prospective,randomized,open and paralleled controlled trial was conducted on patients（aged between 16 and 75） with l chronic hepatitis.The treatment group（129） were given diisopropylamine dichloroacetate plus Stronger NeoMiaophagen.The control group A（117） was given diisopropylamine dichloroacetate plus placebo.And control B（120） was given Stronger Neo-Miaophagen plus placeblo.Observe Clinical Symptoms And Signs everyday.HBV-DNA,Hepatic function,renal function,renal function were Tested every week.Results：There were 366 patients enrolled,129 cases in treatment,117 in the control groupA,120 in control group B.The results show that Significant efficiency（61.24% vs 34.19 % vs19.44%）,ALT（42.03±15.28） vs（54.63±39.28） vs（56.72±36.28）,AST（46.25±21.45） vs（63.85±45.95）,TBIL（17.05±10.63） vs（32.25±31.45） vs（29.37±32.90）decrease extent,Hepatic function recovery time（29.85±23.85）d vs（39.27±19.99）d vs（40.06±20.85） of treatment group were superior to the control group（P〈0.05）.And ALT（3.8% vs 18.8% vs 20%）,AST（4.6% vs 20.5% vs 21.7%） rebound rate of treatment is lower than the control group.Besides there is no adverse effect increased in treatment group.Conclusion：There has clinical cooperativity of diisopropylamine dichloroacetate plus Stronger Neo-Miaophagen in treatment with chronic hepatitis.Combine Medication can improve clinical effect and decrease recovery time of hepatic function with no adverse effect increased.