维生素C对重症急性胰腺炎患者血浆D-二聚体的影响

The Effect of D-dimer in Plasma on Patients with Severe Acute Pancreatitis with Vitamin C

目的:探讨维生素C对重症急性胰腺炎(SAP)患者血浆D-二聚体的影响。方法:将40例无凝血功能障碍的SAP患者随机分为两组:常规治疗组和维生素C组,维生素C组在常规治疗的基础上加用维生素,于500ml 5%葡萄糖溶液稀释后静滴,1次/次,连用7天。常规治疗组每日补充人体正常需要量1g维生素C。另取20名健康体检者为正常对照组。分别检测两组患者治疗前及治疗后第7天的血浆D-二聚体水平。结果:治疗前两组患者血浆D-二聚体水平差异无显著意义(P>0.05),但与对照组相比均显著升高(P<0.01);治疗7天后,维生素C组患者血浆D-二聚体水平显著下降,与常规治疗组患者相比差异具有统计学意义(P<0.01)。结论:SAP患者血浆D-二聚体水平明显升高,维生素C能显著降低血浆D-二聚体水平,改善患者的凝血功能,对SAP可能具有辅助治疗作用。

Objective：To investigate the effect of D-dimer on patients with severe acute pancreatitis（SAP）with vitamin C.Methods：40 cases without coagulation dysfunction in patients with SAP were randomly divided into 2 groups：conventional treatment group and vitamin C group.In vitamin C group on the basis of conventional treatment,vitamin C 2g were diluted in 5% dextrose 500ml,intravenous dripped daily 1 times,continues 7 days,and the conventional treatment group with 1g vitamin C/day.Another 20 healthy persons were assigned to control group.The level of D-dimer in plasma was measured in two groups before treatment and after treatment of the seventh day.Results：The level of D-dimer in plasma in two groups before treatment had no significant difference（P〉0.05）,but increased significantly compared with the control group（P〈0.01）;In the seventh day the level of D-dimer in plasma in the vitamin C group decreased significantly,compared with the conventional treatment group（P〈0.01）.Conclusion：The level of D-dimer in plasma were significantly elevated in the patients with SAP.Vitamin C can significantly reduce the level of D-dimer in plasma,improve the coagulation function,and may make the role of adjuvant therapy.