摘要
为胺的 chemoselective N-benzyloxycarbonylation 的一个有效、 eco 友好的协议被描述。有本甲基 chloroformate (Cbz-Cl ) 的胺的反应在优秀收益面对在房间温度的 PEG-600 负担得起相应 N-Cbz 衍生物。方法对 N-Cbz 保护适用脂肪族(非循环、周期) 并且芳香的胺。
An efficient and eco-friendly protocol for the chemoselective N-benzyloxycarbonylation of amines was described.The reaction of amines with benzyl chloroformate（Cbz-Cl） in the presence of PEG-600 at room temperature afforded the corresponding N-Cbz derivatives in excellent yields.The method is applicable to the N-Cbz protection of aliphatic（acyclic and cyclic） and aromatic amines.
基金
the National Science and Technology Project of China(No.2009ZX09102-054)for financial support
