甘露醇对癌痛止痛效果临床观察

Clinical observation of mannitol as pain-reliever for cancer pain

目的 :通过临床应用甘露醇 ,观察其对 1 0 8例恶性肿瘤疼痛的止痛效果及实用性。方法 :ivgtt2 0 %甘露醇 2 5 0ml,随机分为qd组和bid组 ,对两组止痛效果进行比较 ;对恶性肿瘤放射治疗病例 ,分为单纯放射治疗组和放射治疗加ivgtt甘露醇组 ,观察放射治疗引起 4、5、6级疼痛出现率。结果 :ivgtt2 0 %甘露醇 2 5 0ml,qd和bid组 ,止痛效果CR分别为 68 5 %和 70 6% (P >0 0 5 ) ;单纯放射治疗组和放射加ivgtt甘露醇组 ,出现 4、5、6级疼痛率分别为 1 2 5 %和 0 (P <0 0 0 1 )。结论

OBJECTIVE:To study the effect of mannitol as pain-reliever for malignant tumor pain.METHODS:320 patients with malignant tumor pain,divided into once daily group and twice daily group,were given 20% mannitol 250ml by intravenous infusion.To compare the effect of relieve pain of mannitol,the malignant tumor patients treated with radiotherapy were divided into purely radiotherapy group and radiotherapy plus intravenous drip mannitol group.RESULTS:The rates completely relieve about the two groups were 68.5% and 70.6%( P >0.05).The rates of 4,5 and 6 pain degree about purely radiotherapy were higher than that of radiotherapy plus mannitol group(12.5% and 0)( P <0.01).CONCLUSION:Intravenous drip mannitol can prevent and kill the acute cancer pain and the pain results from radiotherapy.