摘要
目的 :筛选乙酰螺旋霉素片最佳处方。方法 :考察预胶化淀粉、低取代羟丙基纤维素和吐温 -80对乙酰螺旋霉素片的质量影响 ,并与 2种市售乙酰螺旋霉素片作溶出度比较。结果 :筛选的最佳处方制备的乙酰螺旋霉素片 ,体外溶出度大为提高。结论 :本法处方合理 ,工艺简单 。
OBJECTIVE:To obtain the optimum prescription of acelylspiramycin tablets.METHODS:The effect of CMS-Na,L-HPC,and Tween-80 on the quality of acetylspiramycin tablets were studied.Its dissolvability was determined and compared with those manufactured by two different factories.RESULTS:The results showed that acetylspiramycin tablets prepared with this optimum prescription was much better in terms of dissolvability.CONCLUSION:The method is reasonable,simple,and prodruction suitable to pharmaceutical factiories.
出处
《药学实践杂志》
CAS
2000年第3期149-150,共2页
Journal of Pharmaceutical Practice
关键词
乙酰螺旋霉素片
溶出度
L-HPC
吐温-80
acetylspiramycin tablets
dissolvability
pregelatinized starch
L-HPC
tween-80
