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CXCL12/CXCR4轴介导的信号通路与急性白血病 被引量：3

CXCL12/CXCR4 Axis Mediated Signal Pathway and Acute Leukemia
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摘要 趋化因子受体CXCR4与其特异性配体CXCL12结合,形成CXCL12/CXCR4生物学轴,可以介导体内多个信号通路的转导,并受多种因子的调节,与白血病细胞的存活、生长、迁移、浸润、耐药、复发等密切相关。针对CXCL12/CXCR4轴的靶向治疗为白血病的治疗开辟了新途径。 Chemokine receptor CXCR4 and its specific ligand CXCL12 combined with the formation of CXCL12/CXCR4 bio- logical axis. It can be mediated by multiple signaling pathways, and is subject to a variety of cytokines. The survival, growth,migration,invasion, drug resistance and relapse of the leukemia cell are closely related with CXCL12/CXCR4. The targeted therapy according to CXCL12/CXCR4 axis of for leukemia treatment has opened up a new way.
作者 傅磊 李振江 杨桂玲
机构地区 南昌大学第二附属医院血液科
出处 《医学与哲学（B）》 2012年第7期40-41,52,共3页 Medicine & Philosophy(B)
基金 国家自然科学基金 项目编号:30800490 江西省自然科学基金 项目编号:2007GQY1185
关键词 CXCL12/CXCR4轴 白血病 信号通路 调节因子 治疗 CXCL12/CXCR4, leukemia, signaling pathway, cytokines, therapy
分类号 R733.71 [医药卫生—肿瘤]
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参考文献19

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同被引文献24

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  • 10熊斌,王崇树.趋化因子受体CXCR4和CCR7在甲状腺癌中的表达及其临床病理意义[J].中国普外基础与临床杂志,2011,18(12):1301-1304. 被引量：8

引证文献3

二级引证文献11

医学与哲学（B）
2012年 第7期

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