白细胞介素-1受体拮抗剂在心肌再灌注损伤中的保护作用被引量：1

下载PDF

导出

摘要缺血-再灌注损伤(IRI)一直是威胁急性心机梗死(AMI)IR后心肌存活和手术成功的关键因素,是一个包括细胞代谢紊乱,水电解质失调和细胞凋亡坏死等多种病理变化的复杂现象。Ca2+超载,活性氧族(ROS)的产生和炎症反应被认为是IRI相关的主要机制。白细胞介素-1(IL-1)作为炎症反应中的主要炎症因子在IRI中发挥了重要的作用,大量研究表明,IL-1的受体拮抗剂(IL-1Ra)在IRI中有很好的预防和保护作用,通过阻断IL-1介导的炎症反应和凋亡通路的激活,减轻局部IR诱导的的炎症反应和细胞凋亡坏死,从而减小了心肌梗死范围。

作者熊筱伟张瑞岩

机构地区上海交通大学医学院附属瑞金医院心脏科

出处《国际心血管病杂志》 2012年第4期195-197,共3页 International Journal of Cardiovascular Disease

关键词缺血-再灌注损伤白细胞介素-1受体拮抗剂急性心肌梗死

分类号 R542.22 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献23

1Abbate A, Salloum FN , Vecile E, et al. Anakinra, a recombinant Human Interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction[J]. Circulation, 2008, 117(20) : 2670-2683.
2Verma S, Fedak PW, Weisel RD, et al. Fundamentals of reperfusion injury for the clinical cardiologist[J]. Circulation, 2002, 105(20) : 2332-2336.
3Suleiman MS, Zacharowski K, Angelini GD. Inflammatory response and cardio-protection during open heart surgery~ the importance of anaesthetics[J]. Br J Pharmacol, 2008, 153 (1) : 21-33.
4Dreyer WJ, Michael LH, West MS, et al. Nuetrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion[J]. Circulation, 1991, 84(1): 400-411.
5Vinten-Johansen J, Jiang R, Reeves JG, et al. Inflammation, pro- inflammatory mediators and myocardial ischemla-reperfusion injury[J]. Hematol Oncol Clin North Am, 2007, 21(1) :123- 145.
6Carden DL, Granger DN. Pathophysiology of ischaemia- reperfusion injury[J]. J Pathol, 2000, 190(3) : 255-266.
7Eltzsching HK, Collard CD. Vascular ischemic and reperfusion injury[J]. Br Med Bull, 2004, 70: 71-86.
8Frangogiannis NG, Smith CW, Enyman ML. The inflammatory response in myocardial infarction[J]. Cardiovasc Res, 2002, 53(1) :31-47.
9Dinare[lo CA. InterIeukin-1 and interleukln-1 antagonism[J]. Blood, 1991,77(8) : 1627-1652.
10Tedgui A, Mallat Z. Anti-inflammatory mechanism in the vascular wall[J]. Circ Res, 2001, 88(9) : 877-887.