甲状腺激素在心脏缺血-再灌注中的作用机制
摘要
甲状腺激素对心血管系统有许多作用,其对心肌收缩力、心脏节律和血管功能的作用早已得到认识。然而,越来越多的证据表明,甲状腺激素T3能减轻心脏缺血-再灌注损伤,同时在抑制心脏重构中起重要作用。此文对甲状腺激素在心肌缺血-再灌注以及心脏重构的作用和机制作一介绍。
出处
《国际心血管病杂志》
2012年第4期198-200,共3页
International Journal of Cardiovascular Disease
参考文献26
-
1Kumar A, Taliyan R, Sharma PL. Evaluation of thyroid hormone induced pharmacological preconditioning on cardiomyocyte protection against ischemic-reperfusion injury [J]. Indian J Pharmacol, 2012, 44(1) : 68-72.
-
2Vogt S, Portig I, Irqsusi M, et al. Heat shock protein expression and change of eytochrome c oxidase activity~ presence of two phylogenic old systems to protect tissues in ischemia and reperfusion[J]. J Bioenerg Biomembr, 2011, 43 (4): 425-435.
-
3Cross HR, Murphy E, Bolli R, et al. Expression of activated PKC epsilon (PKC epsilon) protects the ischemic heart, without attenuating ischemie H ( + ) production[J]. J Mol Cell Cardiol, 2002, 34(3): 361 -367.
-
4Dreixler JC, Shaikh AR, Shenoy SK, et al. Protein kinase C subtypes and retinal ischemic preconditioning[J]. Exp Eye Res, 2008, 87(4);300-311.
-
5Pantos CI, Malliopoulou VA, Mourouzis IS, et al. Long- term thyroxine administration protects the heart in a pattern similar to isehemie preconditioning[J]. Thyroid, 2002, 12 (4) :325-329.
-
6Mackay K, Mochly-Rosen D. An inhibitor of p38 mitogen- activated protein kinase protects neonatal cardiac myocytes from ischemia[J]. J Biol Chem, 1999, 274(10) : 6272-6279.
-
7Downey JM, Cohen MV, Cokkinos DV, et al. lschemic preconditioning in myocardial Ischemia~ from Mechanisms to Therapeutic Potentials[M]. New York,2008, 99- 112.
-
8Pantos C, Xinaris C, Mourouzis I, et al. Thyroid hormone changes cardiomyocyte shape and geometry via ERK signaling pathway: potential therapeutic implications in reversing cardiac remodeling?[J]. Mol Cell Biochem, 2007, 297(1-2) : 65-72.
-
9Sun Y, MacRae TH. The small heat shock proteins and their role in human disease[J]. FEBS J, 2005, 272 (11): 2613-2627.
-
10Huot J, Houle F, Spitz DR, et al. HSP27 phosphorylation- mediated resistance against aetin fragmentation and cell death induced by oxidative stress[J]. Cancer Res, 1996, 56(2): 273-279.
-
1樊雨良,秦惠勋,陆遥,王美雯,许勇锋,刘沁,候玲毅,查惠芳,卓霞.尿毒症性心脏损害患者心脏重构的声像检查及临床研究(附68例病例报告)[J].中国心血管杂志,1998,3(6):489-450.
-
2彭涛,胡昭,卜培莉.非透析慢性肾功能衰竭患者心脏重构/功能在超声中变化的研究[J].中国超声诊断杂志,2005,6(4):257-260.
-
3赵振林,李家成,王敬弘.甲状腺激素T_3对心脏的作用及其临床应用[J].山西临床医药,1999,8(1):47-49.
-
4魏垒,陈雄德,马启玲,时立新,潘巨文.甲状腺激素T_3、T_4与急性脊髓损伤间的关系[J].中国脊柱脊髓杂志,1994,4(2):66-67.
-
5陈群清.甲状腺激素T_3在心脏手术中的应用[J].中华胸心血管外科杂志,1996,12(4):244-245. 被引量：6
-
6吉冰洋,王伟鹏,冯正义,李波,龙村,李立环.乌司他丁对心脏直视术中缺血-再灌注损伤的保护作用[J].临床麻醉学杂志,2002,18(9):457-459. 被引量：7
-
7赵振林,李家成,邓勇志.再灌注期应用甲状腺激素T_3对冠状动脉阻力的影响[J].中华胸心血管外科杂志,2000,16(3):165-165. 被引量：2
-
8张艳,张炳山,王澈,武欣迎,包明威,梁锦军,李海涛,杨波.Mindin在心力衰竭家兔心脏中的表达[J].广东医学,2016,37(8):1132-1135.
-
9都健,张峻,刘国良.血管加压素在腹主动脉-下腔静脉分流术后大白鼠心脏重构中的作用[J].中国实用内科杂志,2000,20(8):466-468.
-
10赵振林,李家成,王敬弘,马杰,郭光伟.甲状腺激素T_3增补于心脏停搏液中对心肌的保护作用[J].中华实验外科杂志,1999,16(6):543-544. 被引量：1
