炎症因子CTRP1血清水平与冠心病的研究

Increased serum CTRP1 levels are associated with the presence and severity of coronary artery disease

目的:探讨补体C1q肿瘤坏死因子相关蛋白1(CTRP1)血清水平与稳定型心绞痛(SA)和急性冠脉综合征(ACS)的关系。方法:将1263例在我院接受冠状动脉造影的患者分为正常对照组(n=396)、SA组(n=451)和ACS组(n=416)。再将ACS组分为ST段抬高型心梗组(STEMI)和不稳定型心绞痛/非ST段抬高型心梗(UA/NSTEMI)组。采用酶联免疫吸附法(ELISA)检测血清CTRP1水平。结果:ACS组血清CTRP1水平明显高于其他两组,SA组血清CTRP1水平显著高于正常对照组。STEMI组血清CTRP1水平显著高于UA/NSTEMI组(P<0.01)。SA亚组分析显示,多支病变组血清CTRP1显著高于单支病变组。冠心病患者血清CTRP1水平与肿瘤坏死因子-α(TNF-α)、高敏C反应蛋白(hsCRP)水平呈正相关。结论:CTRP1可能参与冠心病发病。

Objective：To analyze serum levels of Clq/TNF-related protein （CTRP） 1 in patients with stable angina （SA） and acute coronary syndrome （ACS） for potential association of CTRP1 with these diseases. Methods.. A total of 1263 participants were included in this study, categorized as control group （n= 396）, SA group （n = 451） and ACS group （n = 416）. Serum levels of CTRP1 protein were analyzed using commercially available ELISA kits. Results： Serum CTRP1 levels were significantly elevated in patients with coronary artery disease （CAD）, and were the highest in the ACS group （for all comparison, P〈0.01）. This bio-measurement was further analyzed by classifying ACS patients into ST- segment elevation myocardial infarction （STEMI） and unstable angina /non- ST-segment elevation myocardial infarction （UA/NSTEMI） subgroups. As expected, STEMI patients had higher CTRP1 levels than UA/NSTEMI patients. Among the SA group, a greater serum level of CTRP1 was observed in patients with multi-vessel coronary artery disease. Moreover, CTRP1 was positively correlated with tumor necrosis factor （TNF）-α and high sensitivity C-reactive protein （hsCRP） levels. Conclusion： Serum CTRP1 levels are associated with the presence and severity of CAD, indicating that CTRP1 is involved in the pathophysiology of CAD.