枸橼酸坦度螺酮辅助治疗功能性消化不良的疗效分析

The efficiency analysis of tandospirone citrate in the adjuvant therapy of functional dyspepsia

目的观察枸橼酸坦度螺酮辅助治疗功能性消化不良（FD）的临床疗效。方法选取2009年1月至2012年1月收治的89例FD患者，按随机数字表法分为治疗组47例和对照组42例。对照组给予常规促胃肠动力、抑制胃酸等治疗，治疗组在对照组基础上给予枸橼酸坦度螺酮治疗。比较治疗后两组总体疗效和焦虑、抑郁量表评分。结果治疗组总有效率为91．5％（43／47），对照组为76，2％（32／42），两组比较差异有统计学意义（P〈0．01）。治疗组治疗后焦虑量表评分为（51．1±16．2）分，抑郁量表评分为（54．4±14．7）分，对照组分别为（62．6±15.3）、（67．5±11．3）分，两组比较差异有统计学意义（P〈0．05）。结论枸橼酸坦度螺酮治疗FD患者可改善临床症状，安全有效，值得临床推广应用。

Objective To observe the therapeutic effect of tandospirone citrate in the adjuvant therapy of functional dyspepsia （FD）. Methods Eighty-nine FD patients from January 2009 to January 2012 were selected and divided by random digits table method into treatment group （47 cases） and control group （42 cases ）. The patients in control group were treated with conventional therapy to promote stomach bowel power and inhibit gastric acid, while those in treatment group were added tandospirone citrate on the basis of conventional therapy. The overall therapeutic effect, anxiety and depression scale scores of two groups before and after treatment were compared. Results The overall effective rate was 91.5% （43/47） in treatment group and 76.2% （32/42） in control group, which had statistical significance between two groups （P 〈0.01）. The anxiety scale score in treatment group after treatment was （51.1 ± 16.2） scores and depression scale score was （54.4 ± 14.7） scores,while the scores in control groups were （62.6 ± 15.3） （67.5 ± 11.3） scores,respectively. There was significant difference between two groups （P 〈0.05）. Conclusions Tandospirone citrate in treating FD patients can improve the clinical symptoms with safety and effect. Therefore, it is worthy of application.