摘要
半成熟树突状细胞(smDC)缺乏炎性细胞因子作为炎性递质,抗原呈递时不引起T细胞向产生干扰素γ的效应性T细胞(Th1)极化,而是激活CD4+CD25+Tr细胞,诱导抗原特异性免疫耐受;同时其高表达主要组织相容性复合体Ⅱ、CD80和CD86等分子,利于抗原呈递和激活Tr细胞诱导免疫耐受。CD4+CD25+Tr细胞通过表面转化生长因子β/转化生长因子β受体、协同刺激分子,抑制细胞表面分子和免疫调节性细胞因子的表达,抑制免疫反应。
Semimature dendritic cells （smDC）are short of inflammatory eytokines as mediator. During anti- gen-presenting, it activates CD4＋ CD25＋ T regulatory（Tr） cells rather than inducing T cell converting to effector T eellto produce interferon-ywhich can induce antigen-special immune tolerance; smDCs express high levels of MHC-Ⅱ ,CDso ,CD86 and so on,which is beneficial to antigen presenting and activating Tr cell to induce immune tolerance. CD4＋ CD25＋ Tr cells restrict immunoreaction by inhibiting the expression of cell surface molecules and immunomodulatory cytokines through TGF-β/TGF-βreeeptor,eostimulatory molecules.
出处
《医学综述》
2012年第14期2165-2167,共3页
Medical Recapitulate
基金
云南省应用基础研究面上项目联合专项(2008CD023)
云南省社会发展科技计划应用基础研究专项面上项目(2010ZC127)
