摘要
表观遗传调控在肿瘤的形成、发展、转移中起着重要作用,为研究肿瘤的发生机制及预防、诊断和治疗提供了重要线索。DNA甲基化是表观遗传学中研究比较成熟的一种修饰形式,是肿瘤发生、发展的分子机制之一。在此详细论述了DNA甲基化在结直肠癌与肿瘤基因/抑癌基因间的关系,目的为治疗结直肠癌提供新的思路。
The epigenetic events play a significant role in the formation, development and metastasis of tumors ,which provides significance clues to mechanism of neoplasms and how to prevent, diagnose and treat the human tumors in the scientific research. DNA methylation is an important epigenetic modification, one of the molecular mechanisms of tumorigenesis and development. Here is to discuss DNA methylation in coloreetal cancer and tumor gene/tumor suppressor gene,to provide new ideas to treat coloreetal cancer.
出处
《医学综述》
2012年第14期2189-2191,共3页
Medical Recapitulate
基金
三峡大学研究生科研创新基金资助(2011CX063)
